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Alexey E. Lyashkov
Researcher at National Institutes of Health
Publications - 56
Citations - 2340
Alexey E. Lyashkov is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Diastolic depolarization & Sinoatrial node. The author has an hindex of 25, co-authored 50 publications receiving 1860 citations. Previous affiliations of Alexey E. Lyashkov include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
High Basal Protein Kinase A–Dependent Phosphorylation Drives Rhythmic Internal Ca2+ Store Oscillations and Spontaneous Beating of Cardiac Pacemaker Cells
Tatiana M. Vinogradova,Alexey E. Lyashkov,Weizhong Zhu,Abdul M. Ruknudin,Syevda Sirenko,Dongmei Yang,Shekhar H. Deo,Matthew A. Barlow,Shavsha Johnson,James L. Caffrey,Ying Ying Zhou,Ying Ying Zhou,Rui-Ping Xiao,Heping Cheng,Michael D. Stern,Victor A. Maltsev,Edward G. Lakatta +16 more
TL;DR: It is shown that a high basal cAMP level of isolated rabbit SANC and its attendant increase in protein kinase A (PKA)-dependent phosphorylation are obligatory for the occurrence of spontaneous, basal LCRs and for spontaneous beating and is crucial for both basal and reserve cardiac pacemaker function.
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Biophysical Characterization of the Underappreciated and Important Relationship Between Heart Rate Variability and Heart Rate
Oliver Monfredi,Alexey E. Lyashkov,Anne Berit Johnsen,Shin Inada,Heiko Schneider,Ruoxi Wang,Mahesan Nirmalan,Ulrik Wisløff,Victor A. Maltsev,Edward G. Lakatta,Henggui Zhang,Mark R. Boyett +11 more
TL;DR: It is suggested that the correlation between a change inHRV and altered morbidity and mortality is substantially attributable to the concurrent change in HR, and calls for re-evaluation of the findings from many articles that have not adjusted properly or at all for HR differences when comparing HRV in multiple circumstances.
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Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization
Tatiana M. Vinogradova,Ying Ying Zhou,Victor A. Maltsev,Alexey E. Lyashkov,Michael D. Stern,Edward G. Lakatta +5 more
TL;DR: It is concluded that diastolic LCRs reflect rhythmic intracellular Ca2+ cycling that does not require the concomitant membrane depolarization, and that LCR periodicity is closely linked to the spontaneous cycle length.
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Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
Ceereena Ubaida-Mohien,Alexey E. Lyashkov,Marta Gonzalez-Freire,Ravi Tharakan,Michelle Shardell,Ruin Moaddel,Richard D. Semba,Chee W. Chia,Myriam Gorospe,Ranjan Sen,Luigi Ferrucci +10 more
TL;DR: It is proposed that changes in the splicing machinery enables muscle cells to respond to a rise in damage with aging, and is performed quantitative proteomic analysis from skeletal muscle collected from 58 healthy persons aged 20 to 87 years.
Journal ArticleDOI
Membrane Potential Fluctuations Resulting From Submembrane Ca2+ Releases in Rabbit Sinoatrial Nodal Cells Impart an Exponential Phase to the Late Diastolic Depolarization That Controls Their Chronotropic State
Konstantin Y. Bogdanov,Victor A. Maltsev,Tatiana M. Vinogradova,Alexey E. Lyashkov,Harold A. Spurgeon,Michael D. Stern,Edward G. Lakatta +6 more
TL;DR: Beat-to-beat Vm fluctuations during late DD phase reflect the underlying LCR/INCX events, and the ensemble of these events forms the nonlinear DD component that ultimately controls the SANC chronotropic state in tight cooperation with surface membrane ion channels.