M
Megumi Kaneko
Researcher at University of California, San Francisco
Publications - 36
Citations - 2115
Megumi Kaneko is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Visual cortex & Neuroplasticity. The author has an hindex of 17, co-authored 34 publications receiving 1837 citations. Previous affiliations of Megumi Kaneko include Ajinomoto & University of Tokyo.
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Tumor Necrosis Factor-α Mediates One Component of Competitive, Experience-Dependent Plasticity in Developing Visual Cortex
TL;DR: It is suggested that experience-dependent competition in developing visual cortex is the outcome of two distinct, noncompetitive processes, a loss of deprived-eye responses followed by an apparently homeostatic increase in responses dependent on TNFalpha signaling.
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Development of Precise Maps in Visual Cortex Requires Patterned Spontaneous Activity in the Retina
Jianhua Cang,René C. Rentería,Megumi Kaneko,Xiaorong Liu,David R. Copenhagen,Michael P. Stryker +5 more
TL;DR: The findings demonstrate that disrupting early spontaneous activity in the eye alters thalamic connections to the cortex, and shows that the geniculocortical miswiring is not a trivial or necessary consequence of the retinogeniculate defect.
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DNER acts as a neuron-specific Notch ligand during Bergmann glial development
Mototsugu Eiraku,Akira Tohgo,Katsuhiko Ono,Megumi Kaneko,Kazuto Fujishima,Kazuto Fujishima,Tomoo Hirano,Mineko Kengaku +7 more
TL;DR: Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, is identified as a previously unknown ligand of Notch during cellular morphogenesis of Bergmann glia in the mouse cerebellum.
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Ephrin-As Guide the Formation of Functional Maps in the Visual Cortex
TL;DR: The current findings show that the same molecular interactions may operate at successive stages of the visual pathway to organize maps, and indicate that interactions between gradients of EphA/ephrin-A in the cortex guide map formation.
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A cortical disinhibitory circuit for enhancing adult plasticity
TL;DR: Optogenetic activation or genetic blockade of this circuit reveals that it is both necessary and sufficient for rapidly increasing V1 cortical responses following manipulation of visual experience in adult mice, revealing a disinhibitory circuit that regulates adult cortical plasticity.