M
Mei Zhang
Researcher at University of Texas Health Science Center at Houston
Publications - 7
Citations - 1265
Mei Zhang is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Cardiolipin & Inner mitochondrial membrane. The author has an hindex of 6, co-authored 6 publications receiving 1194 citations. Previous affiliations of Mei Zhang include University of Texas at Austin.
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Journal ArticleDOI
Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane.
TL;DR: It is reported here that in a crd1Δ strain of yeast (null in expression of CL synthase) ∼90% of complexes III and IV were observed as individual homodimers; only the supercomplex was observed with CRD1wild type cells, indicating that CL plays a central role in higher order organization of components of the respiratory chain of mitochondria.
Journal ArticleDOI
Cardiolipin is essential for organization of complexes III and IV into a supercomplex in intact yeast mitochondria
TL;DR: Cardiolipin is essential for association of complexes III and IV into a supercomplex in intact yeast mitochondria in the presence of a chaotropic agent, which disrupts the interaction between respiratory complexes.
Journal ArticleDOI
Lack of Mitochondrial Anionic Phospholipids Causes an Inhibition of Translation of Protein Components of the Electron Transport Chain A YEAST GENETIC MODEL SYSTEM FOR THE STUDY OF ANIONIC PHOSPHOLIPID FUNCTION IN MITOCHONDRIA
TL;DR: The molecular basis for the lack of mitochondrial function in PGs1Δ cells is the failure to translate gene products essential to the electron transport chain.
Journal ArticleDOI
Cardiolipin in energy transducing membranes.
TL;DR: The role of cardiolipin in higher order organization of components of the mitochondrial respiratory chain revealed by a combined molecular genetic and biochemical approach is described.
Journal ArticleDOI
The Phosphatidylglycerol/Cardiolipin Biosynthetic Pathway Is Required for the Activation of Inositol Phosphosphingolipid Phospholipase C, Isc1p, during Growth of Saccharomyces cerevisiae
TL;DR: This study provides the first evidence for the mechanism of in vivo activation and function of Isc1p, a Saccharomyces cerevisiae member of the extended family of neutral sphingomyelinases that regulates the generation of bioactive ceramides that mediates at least some functions downstream of PG/CL.