M
Melanie A. Sacco
Researcher at Boyce Thompson Institute for Plant Research
Publications - 8
Citations - 706
Melanie A. Sacco is an academic researcher from Boyce Thompson Institute for Plant Research. The author has contributed to research in topics: Hypersensitive response & Potato virus X. The author has an hindex of 5, co-authored 5 publications receiving 651 citations.
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Journal ArticleDOI
The Coiled-Coil and Nucleotide Binding Domains of the Potato Rx Disease Resistance Protein Function in Pathogen Recognition and Signaling
Gregory J. Rairdan,Sarah M. Collier,Sarah M. Collier,Melanie A. Sacco,T. Baldwin,Teresa Boettrich,Peter Moffett +6 more
TL;DR: A model of CC-NB-LRR function wherein the LRR and CC domains coregulate the signaling activity of the NB domain in a recognition-specific manner is described.
Journal ArticleDOI
The cyst nematode SPRYSEC protein RBP-1 elicits Gpa2- and RanGAP2-dependent plant cell death.
Melanie A. Sacco,Kamila Koropacka,Eric Grenier,Marianne J. Jaubert,Alexandra Blanchard,Aska Goverse,Geert Smant,Peter Moffett,Peter Moffett +8 more
TL;DR: It is demonstrated that the secreted protein RBP-1 from the potato cyst nematode Globodera pallida elicits defense responses, including cell death typical of a hypersensitive response (HR), through the NB-LRR protein Gpa2, which suggests a two-tiered process wherein RanGAP2 mediates an initial interaction with pathogen-delivered Gp-RBP-1 proteins but where the Gpa1 LRR determines which of these interactions will
Journal ArticleDOI
A RanGAP protein physically interacts with the NB‐LRR protein Rx, and is required for Rx‐mediated viral resistance
TL;DR: A novel role for a RanGAP in the function of a plant disease resistance response is demonstrated by co-immunoprecipitation that this interaction is mediated in planta through the putative signaling domain at the Rx amino terminus.
Journal ArticleDOI
Virus resistance induced by NB-LRR proteins involves Argonaute4-dependent translational control.
Saikat Bhattacharjee,Alejandro Zamora,Muhammad Tehseen Azhar,Melanie A. Sacco,Lester H. Lambert,Peter Moffett +5 more
TL;DR: It is shown that the co-expression of a plant NB-LRR protein with its cognate elicitor results in an antiviral response that inhibits the translation of virus-encoded proteins in Nicotiana benthamiana.