M
Melanie S. Flint
Researcher at University of Brighton
Publications - 52
Citations - 1132
Melanie S. Flint is an academic researcher from University of Brighton. The author has contributed to research in topics: Cancer & DNA damage. The author has an hindex of 19, co-authored 47 publications receiving 912 citations. Previous affiliations of Melanie S. Flint include National Institute for Occupational Safety and Health & East Sussex County Council.
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Journal ArticleDOI
Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones
TL;DR: Data show that stress hormones can increase DNA damage and transformation and alter transcriptional regulation of the cell cycle.
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Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer.
Renée L. Flaherty,Matthew Owen,Aidan Fagan-Murphy,Haya Intabli,David Healy,Anika Patel,Marcus Allen,Bhavik Anil Patel,Melanie S. Flint +8 more
TL;DR: It is demonstrated that glucocorticoids may interact with iNOS in a non-genomic manner to produce damaging levels of RNS, thus allowing an insight into the potential mechanisms by which psychological stress may impact breast cancer.
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Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage.
A. Reeder,Myriam A. Attar,L. Nazario,Chandra S. Bathula,A. Zhang,Daniel Hochbaum,E. Roy,Kristine L. Cooper,Steffi Oesterreich,Nancy E. Davidson,Carola A. Neumann,Melanie S. Flint +11 more
TL;DR: A novel mechanism through which stress hormones can induce drug resistance to paclitaxel is described, which may have profound implications for treating drug resistance in patients with TNBC.
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C57BL/6 mice are resistant to acute restraint modulation of cutaneous hypersensitivity.
Melanie S. Flint,Sally S. Tinkle +1 more
TL;DR: Combined application of acute restraint and corticosterone prior to chemical challenge significantly enhanced the ear swelling response in C57BL/6 wild-type mice and demonstrates that stress-resistance is not conferred exclusively through the glucocorticoid pathways.
Journal ArticleDOI
Chronic exposure to stress hormones promotes transformation and tumorigenicity of 3T3 mouse fibroblasts
Melanie S. Flint,Andrew Baum,Britteny Episcopo,Kelly Z. Knickelbein,Angela Liegey Dougall,William H. Chambers,Frank J. Jenkins +6 more
TL;DR: In summary, incubation of 3T3 cells with catecholamines results in long-term DNA damage as measured by increased transformed phenotypes and tumor progression, indicating that they are important mediators of stress effects on genomic instability and vulnerability to tumor formation.