M
Melanie Ziman
Researcher at University of Western Australia
Publications - 97
Citations - 3310
Melanie Ziman is an academic researcher from University of Western Australia. The author has contributed to research in topics: Melanoma & Gene. The author has an hindex of 31, co-authored 96 publications receiving 2825 citations. Previous affiliations of Melanie Ziman include Memorial Sloan Kettering Cancer Center & University of Cape Town.
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Nestin structure and predicted function in cellular cytoskeletal organisation.
TL;DR: In depth studies on the distribution and expression of nestin in mitotically active cells indicate a complex role in regulation of the assembly and disassembly of intermediate filaments which together with other structural proteins, participate in remodeling of the cell.
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Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma.
Elin S. Gray,Helen Rizos,Anna L. Reid,Suzanah C. Boyd,Michelle R. Pereira,Johnny Lo,Varsha Tembe,James Freeman,Jenny H. Lee,Richard A. Scolyer,Kelvin Siew,Chris Lomma,Adam Cooper,Muhammad A. Khattak,Tarek Meniawy,Georgina V. Long,Matteo S. Carlino,Michael Millward,Melanie Ziman +18 more
TL;DR: The data demonstrate that ctDNA is a useful biomarker of response to kinase inhibitor therapy and can be used to monitor tumor evolution and detect the early appearance of resistance effectors.
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Pax genes: regulators of lineage specification and progenitor cell maintenance
Judith A. Blake,Melanie Ziman +1 more
TL;DR: The molecular functions of Pax genes during development are reviewed and the regulatory mechanisms by which they specify and maintain progenitor cells across various tissue lineages are detailed.
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Autoantibody Production in Cancer--The Humoral Immune Response toward Autologous Antigens in Cancer Patients.
TL;DR: Current theories of the causes of autoantibody production in cancer, namely: 1) defects in tolerance and inflammation, 2) changes in protein expression levels, 3) altered protein structure, and 4) cellular death mechanisms are summarized.
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Serologic Autoantibodies as Diagnostic Cancer Biomarkers—A Review
Pauline Zaenker,Melanie Ziman +1 more
TL;DR: The aim of this review is to discuss the relevance of autoantibodies in cancer diagnosis and to outline the current methodologies used in the detection of Autoantibody biomarkers.