Autoantibody Production in Cancer--The Humoral Immune Response toward Autologous Antigens in Cancer Patients.
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TLDR
Current theories of the causes of autoantibody production in cancer, namely: 1) defects in tolerance and inflammation, 2) changes in protein expression levels, 3) altered protein structure, and 4) cellular death mechanisms are summarized.About:
This article is published in Autoimmunity Reviews.The article was published on 2016-05-01 and is currently open access. It has received 170 citations till now. The article focuses on the topics: Autoantibody & Cancer.read more
Citations
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Progress and prospects of early detection in lung cancer
Sean Knight,Phil A. Crosbie,Haval Balata,Jakub Chudziak,Tracy Hussell,Caroline Dive,Caroline Dive +6 more
TL;DR: Despite significant developments in the oncological management of late stage lung cancer over recent years, survival remains poor and the UK Office for National Statistics reported that patients diagnosed with distant metastatic disease had a 1-year survival rate of just 15–19% compared with 81–85% for stage I.
Journal ArticleDOI
Autoantibodies: Opportunities for Early Cancer Detection
TL;DR: Serum immunobiomarkers detected for a range of cancers at an early stage before the development of clinical symptoms could supplement current screening modalities to aid early diagnosis of high-risk populations and assist the clinical management of patients.
Journal ArticleDOI
Region-specific permeability of the blood-brain barrier upon pericyte loss.
Roberto Villaseñor,Basil Kuennecke,Laurence Ozmen,Michelle Ammann,Christof Kugler,Fiona Grüninger,Hansruedi Loetscher,Per-Ola Freskgard,Ludovic Collin +8 more
TL;DR: It is shown that BBB permeability is heterogeneous in pdgf-b ret/ret mice, being significantly higher in the cortex, striatum and hippocampus compared to the interbrain and midbrain, and it is suggested that additional, locally-acting mechanisms may contribute to control of transport.
Journal ArticleDOI
Earlier diagnosis of lung cancer in a randomised trial of an autoantibody blood test followed by imaging
Frank Sullivan,Frances S. Mair,William Anderson,Pauline Armory,Andrew Briggs,Cindy Chew,Alistair Dorward,John Haughney,Fiona Hogarth,Denise Kendrick,Roberta Littleford,Alex McConnachie,Colin McCowan,Nicola McMeekin,Manish G. Patel,Petra Rauchhaus,Lewis D Ritchie,Chris Robertson,John F.R. Robertson,Jose Antonio Robles-Zurita,Joseph Sarvesvaran,Herbert F. Sewell,Michael Sproule,Thomas H. Taylor,Agnes Tello,Shaun Treweek,Kavita Vedhara,Stuart Schembri +27 more
TL;DR: The observation of a stage shift towards earlier-stage lung cancer diagnosis merits further investigations to evaluate whether the EarlyCDT-Lung test adds anything to the emerging standard of low-dose CT.
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Autoantibodies as diagnostic and prognostic cancer biomarker: detection techniques and approaches
Sharda Yadav,Navid Kashaninejad,Mostafa Kamal Masud,Yusuke Yamauchi,Nam-Trung Nguyen,Muhammad J. A. Shiddiky +5 more
TL;DR: This review can potentially guide the researchers towards the development of robust, reliable and sensitive detection strategies for tumor-associated autoantibodies and translation of these biomarkers to real clinical settings for diagnosis and prognosis of cancer.
References
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Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov,Serena Nik-Zainal,Serena Nik-Zainal,David C. Wedge,Samuel Aparicio,Sam Behjati,Sam Behjati,Andrew V. Biankin,Graham R. Bignell,Niccolo Bolli,Niccolo Bolli,Åke Borg,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Sandrine Boyault,Birgit Burkhardt,Adam Butler,Carlos Caldas,Helen Davies,Christine Desmedt,Roland Eils,Jorunn E. Eyfjord,John A. Foekens,Mel Greaves,Fumie Hosoda,Barbara Hutter,Tomislav Ilicic,Sandrine Imbeaud,Sandrine Imbeaud,Marcin Imielinsk,Natalie Jäger,David T. W. Jones,David T. Jones,Stian Knappskog,Stian Knappskog,Marcel Kool,Sunil R. Lakhani,Carlos López-Otín,Sancha Martin,Nikhil C. Munshi,Nikhil C. Munshi,Hiromi Nakamura,Paul A. Northcott,Marina Pajic,Elli Papaemmanuil,Angelo Paradiso,John V. Pearson,Xose S. Puente,Keiran Raine,Manasa Ramakrishna,Andrea L. Richardson,Andrea L. Richardson,Julia Richter,Philip Rosenstiel,Matthias Schlesner,Ton N. Schumacher,Paul N. Span,Jon W. Teague,Yasushi Totoki,Andrew Tutt,Rafael Valdés-Mas,Marit M. van Buuren,Laura van ’t Veer,Anne Vincent-Salomon,Nicola Waddell,Lucy R. Yates,Icgc PedBrain,Jessica Zucman-Rossi,Jessica Zucman-Rossi,P. Andrew Futreal,Ultan McDermott,Peter Lichter,Matthew Meyerson,Matthew Meyerson,Sean M. Grimmond,Reiner Siebert,Elias Campo,Tatsuhiro Shibata,Stefan M. Pfister,Stefan M. Pfister,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,Michael R. Stratton,Michael R. Stratton +84 more
TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
Journal ArticleDOI
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
TL;DR: A unifying conceptual framework called “cancer immunoediting,” which integrates the immune system’s dual host-protective and tumor-promoting roles is discussed.
Journal ArticleDOI
Cancer genes and the pathways they control.
TL;DR: The purposes of this review are to highlight examples of progress in many areas of cancer research, indicate where knowledge is scarce and point out fertile grounds for future investigation.
Journal ArticleDOI
Oncogenic kinase signalling
Peter Blume-Jensen,Tony Hunter +1 more
TL;DR: How oncogenic conversion of protein kinases results from perturbation of the normal autoinhibitory constraints on kinase activity is emphasized and an update is provided on the role of deregulated PI(3)K/Akt and mammalian target of rapamycin/p70S6K signalling in human malignancies.
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