Melanija Tomić

TL;DR: The results indicate that the P2X7 receptor channel dilates under physiological ion conditions, leading to generation of biphasic current, and that this process is controlled by residues near the intracellular side of the channel pore.

TL;DR: The ability of GnRH to exert autocrine actions on its secretory neurons, and to promote episodic release and synchronized discharge of the neuropeptide, could reflect the operation of the endogenous pulse generator and the genesis of the preovulatory GnRH surge in vivo.

TL;DR: It is reported here that anti-PDI agents effectively block CXCR4 Env-mediated fusion and spread of virus infection and support the hypothesis that Env conformational change depends on a well-coordinated action of a tripartite system in which PDI works in concert with the receptor and the coreceptor to effectively lower the activation energy barrier required for EnV conformational rearrangement.

TL;DR: The results provide a molecular link between barrier acquisition in utero and epidermal remodeling after wounding and suggest that the most effective treatments for inflammatory skin disorders might concomitantly suppress the immune response and enhanceEpidermal differentiation to restore the barrier.

TL;DR: It is shown that naive receptors activated and deactivated monophasically at low and biphasically at higher agonist concentrations, and both phases of response were abolished by application of Az10606120, a P2X7R-specific antagonist.