M
Melissa A. Fleegal-DeMotta
Researcher at Saint Louis University
Publications - 7
Citations - 635
Melissa A. Fleegal-DeMotta is an academic researcher from Saint Louis University. The author has contributed to research in topics: Blood–brain barrier & Amyloid beta. The author has an hindex of 7, co-authored 7 publications receiving 567 citations. Previous affiliations of Melissa A. Fleegal-DeMotta include Clarke University & Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease.
Laura B. Jaeger,Laura B. Jaeger,Shinya Dohgu,Shinya Dohgu,Rukhsana Sultana,Jessica L. Lynch,Jessica L. Lynch,Joshua B. Owen,Michelle A. Erickson,Michelle A. Erickson,Gul N. Shah,Gul N. Shah,Tulin O. Price,Tulin O. Price,Melissa A. Fleegal-DeMotta,Melissa A. Fleegal-DeMotta,D. Allan Butterfiled,William A. Banks,William A. Banks +18 more
TL;DR: Inflammation potentially increases brain levels of Abeta by three mechanisms: increased influx, decreased efflux, and increased neuronal production.
Journal ArticleDOI
Angiotensin II Modulates BBB Permeability via Activation of the AT1 Receptor in Brain Endothelial Cells
TL;DR: Results show that Ang II directly modulates transcytotic and paracellular permeability in BBB endothelial cells and could contribute to the pathophysiology of hypertensive encephalopathy.
Journal ArticleDOI
Testing the Neurovascular Hypothesis of Alzheimer’s Disease: LRP-1 Antisense Reduces Blood-Brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition
Laura B. Jaeger,Shinya Dohgu,Shinya Dohgu,Mark C. Hwang,Mark C. Hwang,Susan A. Farr,Susan A. Farr,M. Paul Murphy,Melissa A. Fleegal-DeMotta,Melissa A. Fleegal-DeMotta,Jessica L. Lynch,Jessica L. Lynch,Sandra M. Robinson,Sandra M. Robinson,Michael L. Niehoff,Michael L. Niehoff,Steven N. Johnson,Steven N. Johnson,Vijaya B. Kumar,Vijaya B. Kumar,William A. Banks,William A. Banks +21 more
TL;DR: Dysfunction of LRP-1 at the BBB as a mechanism by which brain levels of Abeta could increase and AD would be promoted supports the neurovascular hypothesis.
Journal ArticleDOI
Nitric Oxide Isoenzymes Regulate Lipopolysaccharide-Enhanced Insulin Transport across the Blood-Brain Barrier
William A. Banks,Shinya Dohgu,Jessica L. Lynch,Melissa A. Fleegal-DeMotta,Michelle A. Erickson,Ryota Nakaoke,Than Q. Vo +6 more
TL;DR: LPS affects insulin transport across the BBB by modulating NOS isoenzyme activity, which suggests that the stimulatory effect of LPS and NOS on insulin transport is mediated through cells of the neurovascular unit other than BECs.
Journal ArticleDOI
Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF
TL;DR: Results show that p44/42 and p38 MAPK signaling pathways mediate the LPS-enhanced release of IL-6 and GM-CSF, which act at the luminal surface of the BMEC to enhance the transcellular transport of HIV-1 independently of actions on paracellular permeability.