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Susan A. Farr
Researcher at Saint Louis University
Publications - 133
Citations - 8258
Susan A. Farr is an academic researcher from Saint Louis University. The author has contributed to research in topics: Hippocampus & Blood–brain barrier. The author has an hindex of 46, co-authored 119 publications receiving 7467 citations. Previous affiliations of Susan A. Farr include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
Ghrelin controls hippocampal spine synapse density and memory performance
Sabrina Diano,Susan A. Farr,Susan A. Farr,Stephen C. Benoit,Ewan C. McNay,Ivaldo Silva,Balazs Horvath,F. Spencer Gaskin,F. Spencer Gaskin,Naoko Nonaka,Naoko Nonaka,Laura B. Jaeger,Laura B. Jaeger,William A. Banks,William A. Banks,John E. Morley,John E. Morley,Shirly Pinto,Robert S. Sherwin,Lin Xu,Kelvin A. Yamada,Mark W. Sleeman,Matthias H. Tschöp,Tamas L. Horvath +23 more
TL;DR: It is reported that circulating ghrelin enters the hippocampus and binds to neurons of the hippocampal formation, where it promotes dendritic spine synapse formation and generation of long-term potentiation.
Journal ArticleDOI
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.
Susan A. Farr,Susan A. Farr,H. Fai Poon,Dilek Dogrukol-Ak,Jeniffer Drake,William A. Banks,Edward Eyerman,D. Allan Butterfield,John E. Morley +8 more
TL;DR: The hypothesis that oxidative stress can lead to cognitive dysfunction and provide evidence for a therapeutic role for antioxidants is supported and the hypothesis that antioxidant treatment can reverse cognitive dysfunction is supported.
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Obesity and hypertriglyceridemia produce cognitive impairment.
Susan A. Farr,Susan A. Farr,Kelvin A. Yamada,D. Allan Butterfield,H. Mohammad Abdul,Lin Xu,Nicole E. Miller,Nicole E. Miller,William A. Banks,William A. Banks,John E. Morley,John E. Morley +11 more
TL;DR: It is concluded that triglycerides mediate cognitive impairment as seen in obesity, possibly by impairing maintenance of the N-methyl-d-aspartate component of hippocampal long-term potentiation, and that lowering triglycerides can reverse the cognitive impairment and improve oxidative stress in the brain.
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Effects of leptin on memory processing.
TL;DR: The results indicate that leptin in the hippocampus is involved in memory processing and suggests that low levels of leptin may be involved in cognitive deficits seen in disease states where leptin transport into the CNS is compromised.
Journal ArticleDOI
β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory
John E. Morley,John E. Morley,Vijaya B. Kumar,Vijaya B. Kumar,Adonis E Bernardo,Adonis E Bernardo,Susan A. Farr,Susan A. Farr,Kayoko Uezu,Kayoko Uezu,Nina Tumosa,Nina Tumosa,James F. Flood,James F. Flood +13 more
TL;DR: This reversal of cognitive deficits provides a link between increased expression of both APP and Abeta protein and learning and memory loss in these mice.