M
Melissa V. Chan
Researcher at Queen Mary University of London
Publications - 63
Citations - 1777
Melissa V. Chan is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 19, co-authored 54 publications receiving 1360 citations. Previous affiliations of Melissa V. Chan include Swansea University & National Institutes of Health.
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Journal ArticleDOI
Association of MicroRNAs and YRNAs with platelet function
Dorothee Kaudewitz,Philipp Skroblin,Lukas H. Bender,Temo Barwari,Peter Willeit,Raimund Pechlaner,Nicholas P. Sunderland,Karin Willeit,Allison Morton,Paul C Armstrong,Melissa V. Chan,Ruifang Lu,Xiaoke Yin,Filipe Gracio,Katarzyna A. Dudek,Sarah R. Langley,Anna Zampetaki,Emanuele de Rinaldis,Shu Ye,Timothy D. Warner,Alka Saxena,Stefan Kiechl,Robert F. Storey,Manuel Mayr +23 more
TL;DR: Levels of platelet-related plasma miRNAs and YRNAs correlate with platelet function tests in patients with acute coronary syndrome and platelet activation markers in the general population.
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In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
Paul C Armstrong,P. D. M. Leadbeater,Melissa V. Chan,Nicholas S. Kirkby,Joseph A. Jakubowski,Jane A. Mitchell,Timothy D. Warner +6 more
TL;DR: P2Y12 receptor blockade alone causes inhibition of platelet aggregation that is little enhanced by aspirin, and the antiaggregatory effects of PAM were associated with reductions in the platelet release of both TXA2 and ATP + ADP.
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Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways.
Nicholas S. Kirkby,Melissa V. Chan,Anne K. Zaiss,Eliana Garcia-Vaz,Jing Jiao,Lisa Berglund,Elena F. Verdu,Blerina Ahmetaj-Shala,John L. Wallace,Harvey R. Herschman,Maria F. Gomez,Jane A. Mitchell +11 more
TL;DR: In the kidney and other sites, constitutive COX-2 expression is a sterile response, independent of commensal microorganisms and not associated with activity of the inflammatory transcription factor NF-κB, which is important for normal homeostatic functions, including those important to the cardiovascular-renal system.
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2018 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.
Jonathan P. Duff,Alexis A. Topjian,Marc D. Berg,Melissa V. Chan,Sarah E. Haskell,Benny L. Joyner,Javier J. Lasa,Sondra J. Ley,Tia T Raymond,Robert M. Sutton,Mary Fran Hazinski,Dianne L. Atkins +11 more
TL;DR: The writing group reaffirmed the 2015 pediatric advanced life support guideline recommendation that either lidocaine or amiodarone may be used to treat pediatric patients with shock-refractory ventricular fibrillation or pulseless ventricular tachycardia.
Journal ArticleDOI
Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics.
John L. Wallace,Rory W. Blackler,Melissa V. Chan,Gabriela Jorge Da Silva,Wagdi Elsheikh,Kyle L. Flannigan,Iulia Gamaniek,Anna Manko,Lu Wang,Jean-Paul Motta,Andre G. Buret +10 more
TL;DR: There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair, and there is strong evidence that novel, H2S-based therapeutics are safe and effective in animal models.