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Anne K. Zaiss
Researcher at University of California, Los Angeles
Publications - 9
Citations - 451
Anne K. Zaiss is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Adenoviridae & Transduction (genetics). The author has an hindex of 8, co-authored 9 publications receiving 387 citations. Previous affiliations of Anne K. Zaiss include University of California, Berkeley.
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Journal ArticleDOI
Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways.
Nicholas S. Kirkby,Melissa V. Chan,Anne K. Zaiss,Eliana Garcia-Vaz,Jing Jiao,Lisa Berglund,Elena F. Verdu,Blerina Ahmetaj-Shala,John L. Wallace,Harvey R. Herschman,Maria F. Gomez,Jane A. Mitchell +11 more
TL;DR: In the kidney and other sites, constitutive COX-2 expression is a sterile response, independent of commensal microorganisms and not associated with activity of the inflammatory transcription factor NF-κB, which is important for normal homeostatic functions, including those important to the cardiovascular-renal system.
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The influence of innate and pre‐existing immunity on adenovirus therapy
TL;DR: Findings using adenovirus vectors in naïve animals, in Ad‐immunized animals and in clinical trials, and review strategies proposed to overcome innate immune responses and pre‐existing immunity are summarized.
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LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
Nicholas S. Kirkby,Nicholas S. Kirkby,Anne K. Zaiss,Paula Urquhart,Jing Jiao,Philip J. Austin,Malak Al-Yamani,Malak Al-Yamani,Martina H. Lundberg,Louise MacKenzie,Timothy D. Warner,Anna Nicolaou,Harvey R. Herschman,Jane A. Mitchell +13 more
TL;DR: The thymus, gut, brain and other tissues are identified as target organs for consideration in developing a new understanding of how COX-2 protects the cardiovascular system.
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Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies.
Nicholas S. Kirkby,Anne K. Zaiss,William R. Wright,Jing Jiao,Melissa V. Chan,Timothy D. Warner,Harvey R. Herschman,Jane A. Mitchell +7 more
TL;DR: Interactions of Toll-like receptors (TLRs) with COX enzymes in vivo are reported and COX-2 inhibition could provide a novel anti-viral therapeutic strategy.
Journal ArticleDOI
Hepatocyte heparan sulfate is required for adeno-associated virus 2 but dispensable for adenovirus 5 liver transduction in vivo
Anne K. Zaiss,Erin M. Foley,Roger Lawrence,Lina S. Schneider,Hamidreza Hoveida,Patrick Secrest,Arthur Catapang,Yu Yamaguchi,Ramon Alemany,Dmitry M. Shayakhmetov,Jeffrey D. Esko,Harvey R. Herschman +11 more
TL;DR: The question of how adenovirus enters cells in vivo is reopens, and the necessity of demonstrating the nature of the receptor by genetic means is emphasized, both for understanding Ad5 entry into cells in vitro and for optimization of Ad5 vectors as therapeutic agents.