Solid phase sensitive palladium(II) ions detection and recovery using ligand based efficient conjugate nanomaterials

Carbon monoxide (CO) is an important gasotransmitter in living systems and its fluorescent detection is of particular interest. However, fluorescent detection of CO in living cells is still challenging due to lack of effective probes. In this paper, a readily available fluorescein-based fluorescent probe was developed for rapid detection of CO. This probe can be used to detect CO in almost wholly aqueous solution under mild conditions and shows high selectivity and sensitivity for CO with colorimetric and remarkable fluorescent turn-on signal changes. The detection limit of this probe for CO is as low as 37 nM with a linear range of 0–30 μM. More importantly, this probe (1 μM dose) can be conveniently used for fluorescent imaging CO in living cells.

Readily Available Fluorescent Probe for Carbon Monoxide Imaging in Living Cells

In this work, a dicyanoisophorone-based fluorophore, which showed an attractive near-infrared fluorescence as well as a favorable large stokes shift, was used to develop a novel probe ( NIR-Probe 1 ) for effective detection of biothiols. It displayed distinct color changes and a turn-on NIR fluorescence response with a high off/on ratio toward biothiols. We demonstrated that NIR-Probe 1 exhibited fast sensing speed, high selectivity for biothiols and possessed the function of detecting low concentration of biothiols with impressive limit of detection: 12.1 nM for Cys, 14.5 nM for Hcy and 11.9 nM for GSH. Moreover, the utility of NIR-Probe 1 as a bioanalytical molecular tool was demonstrated by fluorescence imaging of biothiols in living cells.

A novel near-infrared fluorescent probe with a large stokes shift for the detection and imaging of biothiols

Carbon monoxide (CO) is an important gasotransmitter in living systems. The biological detection of this gasotransmitter is still in its infancy and urgently needs probes. In this paper, a novel fluorescent probe system, which is based on the Pd 0 -mediated Tsuji–Trost reaction, is reported for rapid detection of CO both in in vitro and in living cells. This probe system is readily available and shows excellent sensing properties for CO including rapid and distinct colorimetric and fluorescent turn-on responses, high selectivity and sensitivity with a low detection limit (25 nM) in aqueous solution under mild conditions. In addition, fluorescent imaging of CO in living cells can be conveniently achieved by a low dose of this probe system.

Lighting up carbon monoxide in living cells by a readily available and highly sensitive colorimetric and fluorescent probe

Highly sensitive and selective ESIPT-based fluorescent probes for detection of Pd2+ with large Stocks shifts

A novel colorimetric and fluorescent probe for the highly selective and sensitive detection of palladium based on Pd(0) mediated reaction

Rhodol is an ideal platform for fluorescent probes owing to its spirolactone framework and excellent photochemical properties. Herein, a novel rhodol-based colorimetric and fluorescent turn-on probe, DER-1, for the detection of Pd0, was rationally developed with an allyl carbamate group as the response unit. Base on the Pd0-triggered cleavage reaction and rhodol spiroring-opening mechanism, the proposed probe exhibited a high selectivity and sensitivity towards Pd0. Upon addition of Pd(PPh3)4, a significant fluorescence enhancement at 547 nm was observed with an obvious color change from colorless to pink, which can be easily identified by naked-eye. In addition, the fluorescence intensity at 547 nm was linearly proportional to the concentration of Pd0 in the range of 0–1.5 μM, and the detection limit was calculated to be 1.14 nM. That is, probe DER-1 can be quite a sensitive fluorescent turn-on probe for the quantitative detection of Pd0 in pretty low dose.

Mengmeng Liu

Papers

A novel colorimetric and fluorescent probe for the highly selective and sensitive detection of palladium based on Pd(0) mediated reaction

A novel dual-mode turn-on optional chemodosimeter for the visualization of Pd0 with a low detection limit