M
Mengqi Guo
Researcher at Yantai University
Publications - 4
Citations - 317
Mengqi Guo is an academic researcher from Yantai University. The author has contributed to research in topics: Cancer & Paclitaxel. The author has an hindex of 3, co-authored 4 publications receiving 114 citations.
Papers
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Journal ArticleDOI
ATF3 promotes erastin-induced ferroptosis by suppressing system Xc
Liyuan Wang,Liyuan Wang,Yichen Liu,Tingting Du,Tingting Du,Heng Yang,Lei Lei,Mengqi Guo,Han Fei Ding,Junran Zhang,Hongbo Wang,Xiaoguang Chen,Chunhong Yan +12 more
TL;DR: It is reported that activating transcription factor 3 (ATF3), a common stress sensor, can promote ferroptosis induced by erastin and add ATF3 to a short list of proteins that can regulate system Xc− and promote feroptosis repressed by this antiporter.
Journal ArticleDOI
A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility.
Yun-Tao Ma,Yanting Yang,Pei Cai,Deyang Sun,Pedro A. Sánchez-Murcia,Xiao-Ying Zhang,Wen-Qiang Jia,Lei Lei,Mengqi Guo,Federico Gago,Hongbo Wang,Wei-Shuo Fang +11 more
TL;DR: The resulting compound, 3f, was able to overcome drug resistance in cultured P-gp-overexpressing tumor cells and showed greater activity than docetaxel against drug-resistant A2780/AD ovarian cancer xenografts in mice.
Journal ArticleDOI
Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity.
Jingxuan Ni,Mengqi Guo,Cao Yucheng,Lei Lei,Kangli Liu,Wang Binghua,Fangfang Lu,Rong Zhai,Xiangwei Gao,Chunhong Yan,Hongbo Wang,Yi Bi +11 more
TL;DR: This study highlights the advantage of introducing the medium-length amino-terminal groups at the 3-OH position of FA to enhance its anti-tumor activity and suggests that compound 4 provides a starting point for designing more potent derivatives in the future.
Patent
TRPC6 inhibitor with anti-gastric cancer activity, and preparation method and application thereof
Wang Hongbo,Xuechuan Hong,Fu Fenghua,Yan Chunhong,Lyu Zhenbin,Lei Lei,Ma Jinbo,Zhai Rong,Mengqi Guo +8 more
TL;DR: In this paper, a pyrazolo-[1,5-a] pyrimidine derivative was used for activity screening results of the cell level and target level of the compound and an anti-tumor application for treating diseases or symptoms.