M
Meredith R. Clark
Researcher at Eastern Virginia Medical School
Publications - 54
Citations - 1450
Meredith R. Clark is an academic researcher from Eastern Virginia Medical School. The author has contributed to research in topics: Medicine & Sexual transmission. The author has an hindex of 22, co-authored 47 publications receiving 1216 citations. Previous affiliations of Meredith R. Clark include Conrad Hotels & DSM.
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Journal ArticleDOI
Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy
Justin T. Clark,Meredith R. Clark,Namdev B. Shelke,Todd J. Johnson,Eric M. Smith,Andrew K. Andreasen,Joel S. Nebeker,Judit Fabian,David R. Friend,Patrick F. Kiser +9 more
TL;DR: This system is described, in silico, in vitro and in vivo evaluation of a dual-reservoir intravaginal ring that delivers the HIV-1 reverse transcriptase inhibitor tenofovir and the contraceptive levonorgestrel for 90 days and is the first in a new class of long-acting multipurpose prevention drug delivery systems.
Journal ArticleDOI
Multipurpose Prevention Technologies: Biomedical Tools to Prevent HIV-1, HSV-2, and Unintended Pregnancies
TL;DR: Potent antiviral drugs released topically in the female reproductive tract by innovative delivered systems and formulations will provide safe, effective, and acceptable multipurpose prevention tools.
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A 90-Day Tenofovir Reservoir Intravaginal Ring for Mucosal HIV Prophylaxis
Todd J. Johnson,Meredith R. Clark,Theodore H. Albright,Joel S. Nebeker,Anthony L. Tuitupou,Justin T. Clark,Judit Fabian,R. Tyler McCabe,Neelima Chandra,Gustavo F. Doncel,David R. Friend,Patrick F. Kiser +11 more
TL;DR: The controlled release of TFV from this reservoir IVR provided elevated sheep vaginal concentrations for 90 days to merit its further evaluation as an HIV prophylactic.
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An Intravaginal Ring for the Simultaneous Delivery of Multiple Drugs
Marc M. Baum,Irina Butkyavichene,Joshua Gilman,Sean Kennedy,Etana Kopin,Amanda M. Malone,Cali Nguyen,Thomas J. Smith,David R. Friend,Meredith R. Clark,John A. Moss +10 more
TL;DR: The pod-IVR design enables the vaginal delivery of multiple microbicides with differing physicochemical properties, and is an attractive approach for the sustained intravaginal delivery of relatively hydrophilic drugs that are difficult to deliver using conventional matrix IVR technology.
Journal ArticleDOI
Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies.
TL;DR: The microbicide and MPT IVRs currently in development are reviewed, with a focus on the clinical aspects of IVR assessment and the challenges facing microbicides andMPT IVR product development, clinical testing, and implementation.