Showing papers in "Journal of Pharmaceutical Sciences in 2012"

TL;DR: A brief review assesses tools and materials suggested for increasing the CE for pharmaceutically useful cyclodextrins and drugs.

TL;DR: A number of recommendations were made on issues ranging from the assessment of physical stability of API-polymer dispersions to in vivo GI physiological factors that require consideration in the performance evaluation of these systems.

TL;DR: A detailed review and analysis of currently available in vitro BBB models ranging from static culture systems to the most advanced flow-based and three-dimensional coculture apparatus is provided.

TL;DR: The need for more extensive analytical characterization in relation to concerns about protein instability in injectable drug delivery systems for sustained release is discussed and the potential roles for academic research in further improving protein stability and developing new analytical technologies to detect protein degradation byproducts in novel drug delivery system are described.

TL;DR: In this article, baseline conditions for the conduct of digestion tests are suggested and a series of eight model LBFs are described to probe test performance across different formulation types. Digestion experiments were performed in vitro using a pHstat apparatus and danazol employed as a model poorly water-soluble drug.

TL;DR: In conclusion, the esterase expression and hydrolyzing pattern of dog plasma were found to be closest to that of human plasma, and should be considered when selecting model animals for preclinical studies.

TL;DR: Electrospinning and extrusion of a poorly water-soluble active pharmaceutical ingredient were used to improve its dissolution, which is a major challenge in the field of pharmaceutical technology, and resulted in significantly improved dissolution.

TL;DR: Typical stress methods are addressed within this review, such as exposure to elevated temperatures, freeze-thawing, mechanical stress, oxidation, light, as well as various materials and devices used in the clinics during final administration.

TL;DR: The underlying theory, benefits, shortcomings, and illustrative examples for quantification techniques, as well as characterization techniques for particle shape, morphology, structure, and identity are described.

TL;DR: Application of mesoporous silicon dioxide and silicates in drug amorphization is the main focus and the nature of gas-porous media interactions is summarized, and the behavior of molecules confined in mesopores is compared with those in bulk, crystalline phase.

TL;DR: This paper proposed a standardized nomenclature and classification scheme that can be applied to describe all protein aggregates, including size, reversibility/dissociation, conformation, cova- lent modification, and morphology.

TL;DR: In this commentary, a standardized nomenclature and classification scheme that can be applied to describe all protein aggregates is proposed and five categories are described under which a given aggregate may be independently classified.

TL;DR: The latest evolvement on (111)In-labeled nanoparticles for biodistribution assessment and/or imaging evaluation of nanocarriers, as well as therapy in cancer is overviewed.

TL;DR: A simple molecular computational method is presented to predict the aggregation propensity via hydrophobic interactions, thought to be the most common mechanism of aggregation, and electrostatic interactions, using a new quantity termed Developability Index.

TL;DR: Papers and patents that deal with polymorphism and solvatomorphism and systems where the crystal structures of the substance are defined by different unit cells but where these unit cells differ in their elemental composition through the inclusion of one or molecules of solvent are summarized in an annual review.

TL;DR: The purpose of this work was to understand the viscosity behavior of high-concentration monoclonal antibody (mAb) solutions in a wide range of solution conditions and generate guidelines helpful to formulate products with manageable viscoelasticity.

TL;DR: The original CIJ design was modified to allow hand operation, eliminating the need for a syringe pump, and a second antisolvent dilution stage was added, resulting in a simple, cheap, and efficient device to produce nanoparticles.

TL;DR: An emerging technology subtype that has been adopted by formulators to address low-solubility issues is the supersaturating drug delivery system; this system is based on the "spring" and "parachute" design elements, which have been applied to lipid-based formulations, S(M)EDDS, solid dispersions, nano-based systems, and many others.

TL;DR: Furosemide was screened in cocrystallization experiments with pharmaceutically acceptable coformer molecules to discover cocrystals of improved physicochemical properties, that is high solubility and good stability, that are identified in a solid form screen.

TL;DR: Although, IL-1Ra has broad-spectrum anti-inflammatory activities, it also has some limitations due to its short half-life, and further studies are required to investigate its therapeutic effects against diabetes and diabetes-associated complications.

TL;DR: It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be used for accurate and efficient screening of coformers for active pharmaceutical ingredient (API) cocrystallization.

TL;DR: Liposomes as nanosized phospholipid-based vesicles are expected to solubilize curcumin and enhance its activity, thus serving as an advanced topical formulation in the treatment of vaginal inflammation.

TL;DR: In this article, a review of solution-mediated phase transformation during dissolution is presented, including those involving salts, polymorphs, amorphous solids, and cocrystals.

TL;DR: In this article, a physically stable dispersion in polymers was proposed to improve the dissolution rate of efavirenz (EFV) by formulating an EFV dispersion.

TL;DR: It is demonstrated that the aerodynamic behavior of carrier particles varies markedly with both their physical properties and the inhalation device, significantly influencing the performance of a dry powder inhaler formulation.

TL;DR: The in vivo studies in mice upon microneedle administration show immunogenicity against monovalent H1N1 at doses 0.1 and 1 μg and trivalent vaccine at a dose of 1 μg.

TL;DR: A significant improvement in the mechanism-based prediction of metabolic CL for these 25 highly bound drugs from in vitro data determined with microsomes is demonstrated, which should facilitate the application of physiologically based pharmacokinetic (PBPK) models in drug discovery and development.

TL;DR: Astaxanthin (Asx) would be expected to prevent ultraviolet (UV)-induced skin damage, as it is regarded as a potent antioxidative carotenoid in biological membranes, but it is difficult to administer Asx topically to skin because of its poor water solubility.

TL;DR: In this paper, the authors provide a perspective on the principles that can be applied to determine the need for and the manner in which to control quality attributes when their impact on safety and/or efficacy is suspected, but uncertain.

TL;DR: The pod-IVR design enables the vaginal delivery of multiple microbicides with differing physicochemical properties, and is an attractive approach for the sustained intravaginal delivery of relatively hydrophilic drugs that are difficult to deliver using conventional matrix IVR technology.