M
Merton Bernfield
Researcher at Harvard University
Publications - 84
Citations - 13217
Merton Bernfield is an academic researcher from Harvard University. The author has contributed to research in topics: Syndecan 1 & Heparan sulfate. The author has an hindex of 49, co-authored 84 publications receiving 12854 citations. Previous affiliations of Merton Bernfield include Children's Medical Center of Dallas & Brigham and Women's Hospital.
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Journal ArticleDOI
Functions of Cell Surface Heparan Sulfate Proteoglycans
Merton Bernfield,Martin Götte,Pyong Woo Park,Ofer Reizes,Marilyn L. Fitzgerald,John Lincecum,Masahiro Zako +6 more
TL;DR: Current analyses of genetic defects in Drosophila melanogaster, mice, and humans confirm most of these activities in vivo and identify additional processes that involve cell surface heparan sulfate proteoglycans.
Journal ArticleDOI
Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans
Merton Bernfield,R. Kokenyesi,Masato Kato,Michael T. Hinkes,Jürg Spring,Richard L. Gallo,Edward J. Lose +6 more
Journal ArticleDOI
Specificities of heparan sulphate proteoglycans in developmental processes
TL;DR: To understand both the mechanisms by which ligands involved in development interact with their receptors and how morphogens pattern tissues, biologists need to consider the functions of heparan sulphate proteoglycans in signalling and developmental patterning.
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Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase.
TL;DR: The results demonstrate the existence of highly regulated mechanisms that can rapidly convert syndecans from cell surface receptors or coreceptors to soluble heparan sulfate proteoglycan effectors.
Journal ArticleDOI
Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns.
TL;DR: Most, if not all, cells acquire a distinctive repertoire of the four syndecan family members as they differentiate, resulting in selective patterns of expression that likely reflect distinct functions.