M
Micael Hardy
Researcher at Aix-Marseille University
Publications - 82
Citations - 3585
Micael Hardy is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Superoxide & Spin trapping. The author has an hindex of 25, co-authored 73 publications receiving 2699 citations. Previous affiliations of Micael Hardy include Centre national de la recherche scientifique & Medical College of Wisconsin.
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Journal ArticleDOI
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
Jacek Zielonka,Joy Joseph,Adam Sikora,Micael Hardy,Olivier Ouari,Jeannette Vasquez-Vivar,Gang Cheng,Marcos Lopez,Balaraman Kalyanaraman +8 more
TL;DR: The physicochemical basis for mitochondrial accumulation of lipophilic cations, synthetic chemistry strategies to target compounds to mitochondria, mitochondrial probes, and sensors, and examples of mitochondrial targeting of bioactive compounds are described.
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Boronate Probes as Diagnostic Tools for Real Time Monitoring of Peroxynitrite and Hydroperoxides
TL;DR: From a toxicological perspective, potential applications of boronates and other fluorescent probes to high-throughput analyses of peroxynitrite and hydroperoxides in toxicological studies are highlighted.
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A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds.
Balaraman Kalyanaraman,Gang Cheng,Micael Hardy,Olivier Ouari,Marcos Lopez,Joy Joseph,Jacek Zielonka,Michael B. Dwinell +7 more
TL;DR: This review focuses on the selective antiproliferative and cytotoxic effects of mitochondria-targeted therapeutics (MTTs) in cancer cells and how signaling molecules traditionally linked to tumor cell proliferation affect tumor metabolism and bioenergetics.
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Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies.
TL;DR: The methodologies to detect mitochondria-derived superoxide and hydrogen peroxide using conventional probes as well as newly developed assays and probes are discussed, and the necessity of characterizing the diagnostic marker products with HPLC and LC-MS in order to rigorously identify the oxidizing species is discussed.
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Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells.
Gang Cheng,Jacek Zielonka,Olivier Ouari,Marcos Lopez,Donna McAllister,Kathleen A. Boyle,C.S. Barrios,James Weber,Bryon D. Johnson,Micael Hardy,Michael B. Dwinell,Balaraman Kalyanaraman +11 more
TL;DR: Findings show how improving the mitochondrial targeting of Met enhances its anticancer activities, including aggressive cancers like PDAC in great need of more effective therapeutic options.