Joy Joseph

TL;DR: It is reported that the major function of glucose metabolism for Kras-induced anchorage-independent growth, a hallmark of transformed cells, is to support the pentose phosphate pathway.

TL;DR: The physicochemical basis for mitochondrial accumulation of lipophilic cations, synthetic chemistry strategies to target compounds to mitochondria, mitochondrial probes, and sensors, and examples of mitochondrial targeting of bioactive compounds are described.

TL;DR: It is shown that superoxide generated in several enzymatic or chemical systems oxidizes HE to a fluorescent product that is totally different from ethidium, which could have implications in intracellular detection and imaging of superoxide.

TL;DR: A newly discovered mechanistic difference in DOX-induced apoptotic cell death in normal versus tumor cells will be useful in developing drugs that selectively mitigate the toxic side effects of DOX without affecting its antitumor action.

TL;DR: It is reported that primary human mesenchymal stem cells undergoing differentiation into adipocytes display an early increase in mitochondrial metabolism, biogenesis, and reactive oxygen species (ROS) generation, and this increase was dependent on mTORC1 signaling.