M
Michael A. A. Kratzer
Researcher at Ludwig Maximilian University of Munich
Publications - 4
Citations - 139
Michael A. A. Kratzer is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Iloprost & Platelet activation. The author has an hindex of 4, co-authored 4 publications receiving 130 citations.
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Journal ArticleDOI
Human CLP36, a PDZ-domain and LIM-domain protein, binds to α-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells
Kristin Bauer,Michael A. A. Kratzer,Marcus Otte,Karin Luber de Quintana,Jörg Hagmann,Georg J. Arnold,Christoph Eckerskorn,Friedrich Lottspeich,Wolfgang Siess +8 more
TL;DR: The study shows that CLP36 associates with actin filaments and stress fibers that are formed during shape change and spreading of platelets and during migration and contraction of endothelial cells, and suggests that this association might modulate the function of alpha-actinin-1.
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Interaction of antiplatelet drugs in vitro: aspirin, iloprost, and the nitric oxide donors SIN-1 and sodium nitroprusside.
TL;DR: The study defines the basis for a more effective antiplatelet therapy using a combination of cGMP- and cAMP-elevating and cyclooxygenase-inhibiting drugs and found that two protein substrates of cAMP/SNP-dependent protein kinases were associated with the functional synergism between SIN-1 and iloprost and were synergistically phosphorylated by platelet treatment.
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The Thrombostat system. A useful method to test antiplatelet drugs and diets.
TL;DR: The Thrombostat system proved to be a sensitive method to detect synergistic effects of various antiplatelet drugs in vitro and of a platelet inhibitory diet ex vivo.
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Is primary haemostasis controlled by a 'platelet delay time'? Formulation of a new hypothesis.
TL;DR: If the described physical model is correct, platelet thrombus growth rate is strongly decreased in extreme arterial flow conditions, and the relative independence of in vivo and ex vivo bleeding time on blood platelet concentrations is explained for the first time.