M
Michael Bousamra
Researcher at University of Louisville
Publications - 51
Citations - 2942
Michael Bousamra is an academic researcher from University of Louisville. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 24, co-authored 51 publications receiving 2501 citations. Previous affiliations of Michael Bousamra include Medical College of Wisconsin & Baptist Health.
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Journal ArticleDOI
Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
Katherine Sellers,Matthew P. Fox,Michael Bousamra,Stephen P. Slone,Richard M. Higashi,Donald M. Miller,Yali Wang,Jun Yan,Mariia Yuneva,Rahul Deshpande,Andrew N. Lane,Teresa W.-M. Fan +11 more
TL;DR: PC knockdown induced multinucleation, decreased cell proliferation and colony formation in human NSCLC cells, and reduced tumor growth in a mouse xenograft model are indicated.
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Targeting lactate dehydrogenase-A inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells
Han Xie,Jun-ichi Hanai,Jian-Guo Ren,Lev Kats,Kerri Burgess,Parul Bhargava,Sabina Signoretti,Julia Billiard,Kevin J. Duffy,Aaron K. Grant,Xiaoen Wang,Pawel Lorkiewicz,Sabrina Schatzman,Michael Bousamra,Andrew N. Lane,Richard M. Higashi,Teresa W.-M. Fan,Pier Paolo Pandolfi,Vikas P. Sukhatme,Pankaj Seth +19 more
TL;DR: It is demonstrated that inactivation of LDH-A in mouse models of NSCLC driven by oncogenic K-RAS or EGFR leads to decreased tumorigenesis and disease regression in established tumors, and LDH -A can be a viable therapeutic target forNSCLC, including cancer stem cell-dependent drug-resistant tumors.
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Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
Teresa W.-M. Fan,Andrew N. Lane,Richard M. Higashi,Mohamed A. Farag,Hong-Chang Gao,Michael Bousamra,Donald M. Miller +6 more
TL;DR: PC activation – revealed here for the first time in human subjects – may be important for replenishing the Krebs cycle intermediates which can be diverted to lipid, protein, and nucleic acid biosynthesis to fulfill the high anabolic demands for growth in lung tumor tissues.
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Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancer.
TL;DR: The presence of significant comorbidity and KPS of <70 are both important prognostic factors, but were found to be independent of each other in Stage I NSCLC, and recommended when analyzing the prognostic effects of tumor or treatment-related factors on OS.
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Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype
Min Liu,Min Liu,Fengling Luo,Fengling Luo,Chuanlin Ding,Sabrin Albeituni,Xiaoling Hu,Yunfeng Ma,Yihua Cai,Lacey R. McNally,Mary Ann Sanders,Dharamvir Jain,Goetz Kloecker,Michael Bousamra,Huang-Ge Zhang,Richard M. Higashi,Andrew N. Lane,Teresa W.-M. Fan,Jun Yan +18 more
TL;DR: It is demonstrated that particulate yeast-derived β-glucan, a natural polysaccharide compound, converts polarized alternatively activated macrophages or immunosuppressive TAM into a classically activated phenotype with potent immunostimulating activity.