Michael Buckstein

TL;DR: It is concluded that nucleoside modifications suppress the potential of RNA to activate DCs, and the innate immune system may detect RNA lacking nucleosides modification as a means of selectively responding to bacteria or necrotic tissue.

TL;DR: dTTP is the most abundant deoxynucleoside triphosphate (dNTP) in the cell despite the fact that its precursors, UDP and UTP, are not; all dNTPs decrease through the growth curve but do not have the abrupt drop, as seen with other nucleotides when the cells transition into stationary phase.

TL;DR: This study purified and characterized fragments of the 738-amino acid Rel(Mtb) protein and confirmed the hypothesis that amino acid fragment 1-394 contains both synthesis and hydrolysis activities, amino acids fragment 87-394 containing only (p)ppGpp synthesis activity, and amino acid fragments 1-181 contains only ( p)pp Gpp hydrolytic activity.

TL;DR: In this article , a paradigm shift in trial design, specimen collection and analysis is proposed for window-of-opportunity trials, during which patients receive short-duration pre-surgical therapies, provide a platform for understanding the therapies' mechanisms of action.

TL;DR: In this paper , a phase 2 trial showed very promising ORR when combining transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) for BCLC A patients with a solitary HCC from 4 to 7 cm.