Carbon—hydrogen spin—spin coupling constants

5.05 – Pyridines and their Benzo Derivatives: Synthesis

The butenolide, 3-methyl-2H-furo[2,3-c]pyran-2-one (1), has recently been identified as the germination stimulant present in smoke that promotes the germination of seeds from a wide range of plant species. In this paper, we describe the preparation of a number of analogues of 1 and compare their efficacy in promoting seed germination of three highly smoke-responsive plant species, Lactuca sativa L. cv. Grand Rapids (Asteraceae), Emmenanthe penduliflora Benth. (Hydrophyllaceae), and Solanum orbiculatum Poir. (Solanaceae). The results show that the methyl substituent at C-3 in 1 is important for germination-promoting activity while substitution at C-7 reduces activity. In contrast, bioactivity is mostly retained with analogues substituted at C-4 or C-5.

Preparation of 2H-furo[2,3-c]pyran-2-one derivatives and evaluation of their germination-promoting activity.

Novel purine compounds and tautomers and pharmaceutically acceptable salts thereof are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.

Purine analogs having HSP90-inhibiting activity

Pyrazolopyrimidines and related analogs are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.

Michael D. Cliffton

Papers

Carbon-13 nuclear magnetic resonance spectra of kojic acid and other 4-pyrone derivatives

Bromomaltol: structure and conversion to novel pyridone and pyridine derivatives

Convenient preparative methods for N-aryl-γ-pyridones from γ-pyrones

Enones with strained double bonds. 7. Precursors for substituted bicyclo[3.3.1]nonane systems

Synthesis of aldehyde and carboxylic acid derivatives from 2‐hydroxymethyl‐3‐hydroxy‐4H‐pyran‐4‐one (α‐hydroxymaltol)