M
Michael D. Lewis
Researcher at University of London
Publications - 70
Citations - 3809
Michael D. Lewis is an academic researcher from University of London. The author has contributed to research in topics: Trypanosoma cruzi & Chagas disease. The author has an hindex of 34, co-authored 70 publications receiving 3297 citations. Previous affiliations of Michael D. Lewis include University of Nottingham.
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Journal ArticleDOI
The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania : looking back and to the future
Michael A. Miles,Martin S. Llewellyn,Michael D. Lewis,Matthew Yeo,Rania M. H. Baleela,Sinead Fitzpatrick,Michael W. Gaunt,Isabel Mauricio +7 more
TL;DR: The profound impact of this parallel research on genetic diversity of T. cruzi and Leishmania is described, in the context of epidemiology, taxonomy and disease control.
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Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection.
Martin S. Llewellyn,Michael A. Miles,Hector Jeronimo Carrasco,Michael D. Lewis,Matthew Yeo,Jorge Vargas,Faustino Torrico,Patricio Diosque,Vera da Costa Valente,Sebastião Aldo da Silva Valente,Michael W. Gaunt +10 more
TL;DR: It is demonstrated that silvatic TcI populations are extraordinarily genetically diverse, show spatial structuring on a continental scale, and have undergone recent biogeographic expansion into the southern United States of America.
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Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue‐specific parasite dynamics and heart disease in the absence of locally persistent infection
Michael D. Lewis,Amanda F. Francisco,Martin C. Taylor,Hollie Burrell-Saward,Alex P. McLatchie,Michael A. Miles,John M. Kelly +6 more
TL;DR: The gut is identified as a permissive niche for long‐term T. cruzi infection and canonical features of Chagas disease can occur without continual myocardium‐specific infection, as shown in mice infected with Chronically infected mice.
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The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia.
Claire Seedhouse,Rowena Bainton,Michael D. Lewis,Alexander Harding,Nigel H. Russell,Emma Das-Gupta +5 more
TL;DR: Evidence of a protective effect against AML in individuals with at least one copy of the variant XRCC1 399Gln allele compared with those homozygous for the common allele is provided.
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Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener.
Oscar Franzén,Stephen Ochaya,Ellen Sherwood,Michael D. Lewis,Martin S. Llewellyn,Michael A. Miles,Björn Andersson +6 more
TL;DR: This study provides a framework for further comparative analyses of two major T. cruzi lineages and highlights the need for sequencing more strains to understand fully the genomic composition of this parasite.