M
Michael D. Threadgill
Researcher at University of Bath
Publications - 154
Citations - 3467
Michael D. Threadgill is an academic researcher from University of Bath. The author has contributed to research in topics: Poly ADP ribose polymerase & Trifluoromethyl. The author has an hindex of 34, co-authored 152 publications receiving 3286 citations. Previous affiliations of Michael D. Threadgill include Aberystwyth University & Kurukshetra University.
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Journal Article
Chemopreventive Efficacy and Pharmacokinetics of Curcumin in the Min/+ Mouse, a Model of Familial Adenomatous Polyposis
Sarah Perkins,Richard D. Verschoyle,Kirsti A. Hill,Ifat Parveen,Michael D. Threadgill,Ricky A. Sharma,Marion L. Williams,William P. Steward,Andreas J. Gescher +8 more
TL;DR: The comparison of dose, resulting curcumin levels in the intestinal tract, and chemopreventive potency suggests tentatively that a daily dose of 1.6 g ofCurcumin is required for efficacy in humans, and may be useful in theChemoprevention of human intestinal malignancies related to Apc mutations.
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α-Methylacyl-CoA racemase - an 'obscure' metabolic enzyme takes centre stage
TL;DR: New research in both the metabolism of branched‐chain lipids and their role in cancer is considered, with particular emphasis on the crucial role played by AMACR.
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Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock.
Michelle C. McDonald,Helder Mota-Filipe,James A. Wright,Maha Abdelrahman,Michael D. Threadgill,Andrew S. Thompson,Christoph Thiemermann +6 more
TL;DR: A new synthesis of a water‐soluble and potent PARP inhibitor, 5‐aminoisoquinolinone (5‐AIQ) is reported on, which abolishes the multiple organ injury caused by severe haemorrhage and resuscitation in the anaesthetized rat.
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Design, Synthesis, and Evaluation in Vitro of Quinoline-8-carboxamides, a New Class of Poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) Inhibitor
TL;DR: 3-substituted compounds for inhibition of human recombinant PARP-1 activity showed a requirement for a small narrow group, and substitutes in the 2-position increased potency.
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Inhibition of nitric oxide (NO•) production in murine macrophages by flavones
TL;DR: The results suggest that the flavones can modulate the immune responses and the inflammatory reactions by controlling production of nitric oxide.