Michael Faust

TL;DR: It is proved that summing up PEC/PNEC ratios might serve as a justifiable CA-approximation, in order to estimate in a first tier assessment whether there is a potential risk for an exposed ecosystem if only base-set data are available.

TL;DR: Results even demonstrate that dissimilarly acting chemicals can show significant joint effects, predictable by independent action, when combined in concentrations below individual NOEC values, statistically estimated to elicit insignificant individual effects of only 1%.

TL;DR: In tests with freshwater algae, predicted and determined the toxicity of multiple mixtures of 18 different s-triazines and the toxicity parameter was the inhibition of reproduction of Scenedesmus vacuolatus.

TL;DR: It may be concluded that concentration addition gives a valid estimation of the overall toxicity for multiple mixtures with similar and specific mechanisms of action of the mixture components in this type of biotest.

TL;DR: As the similarity of components is often unknown for mixtures found in the environment, it is concluded that concentration addition may give a realistic worst case estimation of mixture toxicities for risk assessment procedures.