M
Michael Fehr
Researcher at Leibniz University of Hanover
Publications - 16
Citations - 246
Michael Fehr is an academic researcher from Leibniz University of Hanover. The author has contributed to research in topics: Repolarization & QT interval. The author has an hindex of 9, co-authored 16 publications receiving 216 citations.
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Journal ArticleDOI
A new mechanism preventing proarrhythmia in chronic heart failure: rapid phase-III repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacing-induced heart failure.
Gerrit Frommeyer,Peter Milberg,Patricia Witte,Jörg Stypmann,Matthias Koopmann,Martin Lücke,Nani Osada,Günter Breithardt,Michael Fehr,Lars Eckardt +9 more
TL;DR: The aim of the present study was to investigate the mechanism underlying the low proarrhythmic potential of amiodarone in a model of pacing‐induced heart failure.
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Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization
Peter Milberg,Gerrit Frommeyer,Anne Kleideiter,Alicia Jeanette Fischer,Nani Osada,Günter Breithardt,Michael Fehr,Lars Eckardt +7 more
TL;DR: The present study showed for the first time that PUFAs are effective in preventing TdP in an experimental model of long QT2 and LQT3 syndrome due to a reversion of AP prolongation, a reduction of spatial and temporal dispersion of repolarization and a suppression of EAD.
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Effective suppression of atrial fibrillation by the antihistaminic agent antazoline: First experimental insights into a novel antiarrhythmic agent.
Gerrit Frommeyer,Magdalena Sterneberg,Dirk G. Dechering,Sven Kaese,Nils Bögeholz,Christian Pott,Michael Fehr,Harilaos Bogossian,Peter Milberg,Lars Eckardt +9 more
TL;DR: The antiarrhythmic effect could be explained by a significant increase in postrepolarization refractoriness as a result of a more marked increase in aERP as compared with aAPD.
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Additive Proarrhythmic Effect of Combined Treatment with QT-Prolonging Agents.
Gerrit Frommeyer,Christina Fischer,Christian Ellermann,Dirk G. Dechering,Simon Kochhäuser,Philipp S. Lange,Kristina Wasmer,Michael Fehr,Lars Eckardt +8 more
TL;DR: Combined treatment with several non-cardiovascular QT-prolonging agents resulted in a remarkable occurrence of proarrhythmia, indicating an additive and significant prolongation of cardiac repolarization combined with an increased spatial dispersion of repolarized represents the underlying electrophysiological mechanism.
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Dronedarone and digitalis: individually reduced post-repolarization refractoriness enhances life-threatening arrhythmias
Gerrit Frommeyer,Peter Milberg,Jochen Schulze Grotthoff,Dirk G. Dechering,Simon Kochhäuser,Jörg Stypmann,Michael Fehr,Günter Breithardt,Lars Eckardt +8 more
TL;DR: Ouabain treatment resulted in an increased ventricular vulnerability in chronically dronedarone-pretreated control and failing hearts, and led to a significant abbreviation of ventricular repolarization.