S
Sven Kaese
Researcher at University of Münster
Publications - 23
Citations - 858
Sven Kaese is an academic researcher from University of Münster. The author has contributed to research in topics: Atrial fibrillation & Atrial action potential. The author has an hindex of 12, co-authored 21 publications receiving 749 citations.
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Journal ArticleDOI
PITX2c is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression
Paulus Kirchhof,Peter C. Kahr,Sven Kaese,Ilaria Piccini,Ismail Vokshi,H. H. Scheld,Heinrich Rotering,Lisa Fortmueller,Sandra Laakmann,Sander Verheule,Ulrich Schotten,Larissa Fabritz,Nigel A. Brown +12 more
TL;DR: A physiological role for PITx2 in the adult heart is demonstrated and the hypothesis that dysregulation of PITX2 expression can be responsible for susceptibility to atrial fibrillation is supported.
Journal ArticleDOI
Cardiac electrophysiology in mice: a matter of size.
Sven Kaese,Sander Verheule +1 more
TL;DR: In which respects a mouse heart is a miniature human heart, a suitable model for studying mechanisms of cardiac arrhythmias in humans and in which respects human and murine hearts differ are assessed.
Journal ArticleDOI
Connexin diversity in the heart: insights from transgenic mouse models.
Sander Verheule,Sven Kaese +1 more
TL;DR: Mouse models have enhanced the understanding of (patho)-physiological implications of Cx diversity in the heart and in principle connexin-specific modulation of electrical coupling in theheart represents an interesting treatment strategy for cardiac arrhythmias and conduction disorders.
Journal ArticleDOI
Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice
Paulus Kirchhof,Eloi Marijon,Larissa Fabritz,Na Li,Wei Wang,Tiannan Wang,Kirsten Schulte,Juliane Hanstein,Jan S. Schulte,Mathis Vogel,Nathalie Mougenot,Sandra Laakmann,Lisa Fortmueller,Jens Eckstein,Sander Verheule,Sven Kaese,Ariane Staab,Stephanie Grote-Wessels,Ulrich Schotten,Ghassan Moubarak,Xander H.T. Wehrens,Wilhelm Schmitz,Stéphane N. Hatem,Frank U. Müller +23 more
TL;DR: It is concluded that transcription factor CREM is an important regulator of atrial growth implicated in the development of an arrhythmogenic substrate in TG mice.
Journal ArticleDOI
Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.
Andreas Blana,Sven Kaese,Lisa Fortmüller,Sandra Laakmann,Dierk Damke,Kelly A. van Bragt,Jens Eckstein,Ilaria Piccini,Uwe Kirchhefer,Stanley Nattel,Günter Breithardt,Peter Carmeliet,Edward Carmeliet,Ulrich Schotten,Sander Verheule,Paulus Kirchhof,Larissa Fabritz +16 more
TL;DR: Murine hearts bearing an LQT3 mutation show abnormalities in atrial electrophysiology and subtle changes in atrian dimension, including an atrial arrhythmogenic phenotype on provocation, and indicate that murine sodium channel LQTS models may be useful for exploring underlying mechanisms.