M
Michael Friberg Bruun Nielsen
Researcher at Odense University Hospital
Publications - 18
Citations - 489
Michael Friberg Bruun Nielsen is an academic researcher from Odense University Hospital. The author has contributed to research in topics: Pancreatic cancer & Cytoglobin. The author has an hindex of 9, co-authored 17 publications receiving 363 citations. Previous affiliations of Michael Friberg Bruun Nielsen include University of Southern Denmark & Copenhagen University Hospital.
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Journal ArticleDOI
Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells
TL;DR: It is likely that a context-dependent therapeutic modification, rather than pure depletion, of the PC stroma holds potential for the development of new treatment strategies for PC patients.
Journal ArticleDOI
Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen.
Dres Damgaard,Ladislav Šenolt,Michael Friberg Bruun Nielsen,Ger J. M. Pruijn,Claus Henrik Nielsen +4 more
TL;DR: An assay with high specificity for PAD2 activity is presented and it is shown that citrullination of fibrinogen can occur in cell-free synovial fluid from RA patients.
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Using the full PICO model as a search tool for systematic reviews resulted in lower recall for some PICO elements.
Tove Faber Frandsen,Michael Friberg Bruun Nielsen,Christina Louise Lindhardt,Mette Brandt Eriksen +3 more
TL;DR: The results support the existing recommendation not to search for outcomes and find the PICO elements C and O had a lower retrieval potential across the two Cochrane groups and databases also when combining text words and subject headings.
Journal Article
Smoking is associated with increased levels of extracellular peptidylarginine deiminase 2 (PAD2) in the lungs
Dres Damgaard,Michael Friberg Bruun Nielsen,Maria Quisgaard Gaunsbaek,Yaseelan Palarasah,Viggo Svane-Knudsen,Claus Henrik Nielsen +5 more
TL;DR: This first demonstration of increased levels ofextracellular PAD2 in the lungs of smokers supports the hypothesis that smoking promotes extracellular citrullination of proteins.
Journal ArticleDOI
Genetic Alterations within the DENND1A Gene in Patients with Polycystic Ovary Syndrome (PCOS)
Mette Brandt Eriksen,Mette Brandt Eriksen,Michael Friberg Bruun Nielsen,Klaus Brusgaard,Qihua Tan,Qihua Tan,Marianne Andersen,Dorte Glintborg,Michael Gaster +8 more
TL;DR: In this paper, the DENND1A gene was sequenced in white patients with PCOS to identify possible alterations that may be implicated in the PCOS pathogenesis, but a missense SNP (rs189947178, A/C) was identified in one patient and significantly more carriers were found among patients with polycystic ovary syndrome and moderate hirsutism vs. controls.