M
Michael Gaster
Researcher at Odense University Hospital
Publications - 69
Citations - 3865
Michael Gaster is an academic researcher from Odense University Hospital. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 32, co-authored 69 publications receiving 3575 citations. Previous affiliations of Michael Gaster include University of Southern Denmark.
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Journal ArticleDOI
Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes
Mads Holten,Morten Zacho,Michael Gaster,Carsten Juel,Jørgen F. P. Wojtaszewski,Flemming Dela +5 more
TL;DR: It is found that strength training for 30 min three times per week increases insulin action in skeletal muscle in both groups, and the adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade.
Journal ArticleDOI
Strength training increases insulin-mediated glucose uptake, glut4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes
Mads Holten,Morten Zacho,Michael Gaster,Carsten Juel,Jfp Wojtaszewski,Flemming Dela,Susan Tiukinhoy,Carolyn L. Rochester +7 more
TL;DR: It is found that strength training for 30 min three times per week increases insulin action in skeletal muscle in both groups, and the adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade.
Journal ArticleDOI
GLUT4 Is Reduced in Slow Muscle Fibers of Type 2 Diabetic Patients: Is Insulin Resistance in Type 2 Diabetes a Slow, Type 1 Fiber Disease?
TL;DR: A reduction in the fraction of slow-twitch fibers, combined with a reduction in GLUT4 expression in slow fibers, may reduce the insulin-sensitiveGLUT4 pool in type 2 diabetes and thus contribute to skeletal muscle insulin resistance.
Journal ArticleDOI
Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
Raffaele Teperino,Sabine Amann,Martina Bayer,Sean L. McGee,Andrea Loipetzberger,Timothy Connor,Carsten Jaeger,Bernd Kammerer,Lilli Winter,Gerhard Wiche,Kevin Dalgaard,Madhan Selvaraj,Michael Gaster,Robert S. Lee-Young,Mark A. Febbraio,Claude Knauf,Patrice D. Cani,Fritz Aberger,Josef M. Penninger,J. Andrew Pospisilik,Harald Esterbauer +20 more
TL;DR: It is shown that hedgehog signaling rewires cellular metabolism and is identified a cilium-dependent Smo-Ca(2+)-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility.
Journal ArticleDOI
Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes.
TL;DR: The results indicate that the reduced lipid oxidation in diabetic skeletal muscle in vivo may be of genetic origin; it also appears that TAG metabolism is not primarily affected in diabetic muscles under basal physiological conditions.