M
Michael G. Hutchings
Researcher at Imperial Chemical Industries
Publications - 39
Citations - 729
Michael G. Hutchings is an academic researcher from Imperial Chemical Industries. The author has contributed to research in topics: Alkyl & Electronegativity. The author has an hindex of 13, co-authored 39 publications receiving 708 citations. Previous affiliations of Michael G. Hutchings include Technische Universität München.
Papers
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Journal ArticleDOI
Route Design in the 21st Century: The ICSYNTH Software Tool as an Idea Generator for Synthesis Prediction
Anders Bøgevig,Hans-Jürgen Federsel,Fernando Huerta,Michael G. Hutchings,Hans Kraut,Thomas Langer,Peter Löw,Christoph Oppawsky,Tobias Rein,H. Saller +9 more
TL;DR: CSYNTH as discussed by the authors is a computer-aided synthesis design tool that predicts new ideas for route design to that of historical brainstorm results on a series of commercial pharmaceutical targets, as well as literature data.
Book ChapterDOI
A new treatment of chemical reactivity: Development of EROS, an expert system for reaction prediction and synthesis design
Johann Gasteiger,Michael G. Hutchings,Bernd Christoph,Leopold Gann,Christian Hiller,Peter Löw,Mario Marsili,H. Saller,Kazumi Yuki +8 more
TL;DR: In this article, an expert system for the prediction of the course of organic chemical reactions and for the design of organic syntheses has been built, which does not depend on a database of chemical reactions.
Journal ArticleDOI
Residual electronegativity - an empirical quantification of polar influences and its application to the proton affinity of amines
TL;DR: The residual electronegativity of an atom in a molecule can be used as a quantitative measure of the polar infuence of a substituent on reactivity, as exemplified by its ability, with substituents polarisability, to correlate the proton affinity data of 80 amines as discussed by the authors.
Journal ArticleDOI
Quantitative models of gas-phase proton-transfer reactions involving alcohols, ethers, and their thio analogs. Correlation analyses based on residual electronegativity and effective polarizability
TL;DR: On montre que les parametres d'electronegativite et de polarisabilite offrent un nouvel acces aux donnees quantitative de reactivite as mentioned in this paper.
Journal ArticleDOI
Quantification of effective polarisability. Applications to studies of X-ray photoelectron spectroscopy and alkylamine protonation
TL;DR: In this paper, two new empirical methods lead to a quantification of polarisability-derived stabilisation of charge in molecules, taking account of the attentuation of substituent influence as it is further from the charged center.