M
Michael Goodwin
Researcher at National Institutes of Health
Publications - 15
Citations - 641
Michael Goodwin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Structure–activity relationship & Acyloxyacyl hydrolase. The author has an hindex of 8, co-authored 15 publications receiving 570 citations. Previous affiliations of Michael Goodwin include Novartis Institute for Tropical Diseases & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis
Shinya Watanabe,Michael B. Zimmermann,Michael Goodwin,Uwe Sauer,Clifton E. Barry,Helena I. Boshoff +5 more
TL;DR: A chemostat model of M. tuberculosis where growth rate was a function of dissolved oxygen concentration to analyze metabolic adaptation to hypoxia and found major realignments of central metabolism are consistent with a model of oxygen-induced stasis in which an energized membrane is maintained by coupling the reductive branch of the TCA cycle to succinate secretion.
Journal ArticleDOI
Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques
Philana Ling Lin,Véronique Dartois,Paul J. Johnston,Christopher Janssen,Laura E. Via,Michael Goodwin,Edwin Klein,Clifton E. Barry,JoAnne L. Flynn +8 more
TL;DR: The data in the nonhuman primate model of active and latent TB supports targeting bacteria in hypoxic environments for preventing reactivation of latent infection and possibly shortening the duration of therapy in active TB.
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Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli
Pilho Kim,Yong-Mei Zhang,Gautham G. Shenoy,Quynh-Anh Nguyen,Helena I. Boshoff,Ujjini H. Manjunatha,Michael Goodwin,John T. Lonsdale,Allen C. Price,Darcie J. Miller,Ken Duncan,Stephen W. White,Charles O. Rock,Clifton E. Barry,Cynthia S. Dowd +14 more
TL;DR: Results suggest a strict requirement for a conjugated, planar side chain inserting within the condensing enzyme active site, as well as a structurally diverse set of 5-position analogues.
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Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
Pilho Kim,Sunhee Kang,Helena I. Boshoff,Jan Jiricek,Margaret Collins,Ramandeep Singh,Ujjini H. Manjunatha,Pornwaratt Niyomrattanakit,Liang Zhang,Michael Goodwin,Thomas Dick,Thomas H. Keller,Cynthia S. Dowd,Clifton E. Barry +13 more
TL;DR: It is shown that substitution of this oxygen by either nitrogen or sulfur yielded equipotent analogues of the imidazole ring and significant improvements in potency were realized by extending the linker region between the 6-(S) position and the terminal hydrophobic aromatic substituent.
Journal ArticleDOI
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
Xiaojin Li,Ujjini H. Manjunatha,Michael Goodwin,John E. Knox,Christopher A. Lipinski,Thomas H. Keller,Clifton E. Barry,Cynthia S. Dowd +7 more
TL;DR: Results suggest that the nitroreductase that initially recognizes PA-824 is somewhat insensitive to substitutions at the 7-position, suggesting that inherent lattice stability is not likely to be a major factor in limiting solubility.