L
Laura E. Via
Researcher at National Institutes of Health
Publications - 142
Citations - 12517
Laura E. Via is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 58, co-authored 130 publications receiving 10814 citations. Previous affiliations of Laura E. Via include University of Michigan & University of Texas Health Science Center at San Antonio.
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Journal Article
A rapid CTAB DNA isolation technique useful for RAPD fingerprinting and other PCR applications.
Stewart Cn,Laura E. Via +1 more
Journal ArticleDOI
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
Katrin D. Mayer-Barber,Bruno B. Andrade,Sandra D. Oland,Eduardo P. Amaral,Eduardo P. Amaral,Daniel L. Barber,Jacqueline Gonzales,Steven C. Derrick,Ruiru Shi,Nathella Pavan Kumar,Wang Wei,Xing Yuan,Guolong Zhang,Ying Cai,Subash Babu,Subash Babu,Marta Catalfamo,Andres M. Salazar,Laura E. Via,Clifton E. Barry,Alan Sher +20 more
TL;DR: It is demonstrated that interleukin-1 (IL-1) confers host resistance through the induction of eicosanoids that limit excessive type I interferon (IFN) production and foster bacterial containment and it is established that host-directed immunotherapy with clinically approved drugs that augment prostaglandin E2 levels in these settings prevented acute mortality of Mtb-infected mice.
Journal ArticleDOI
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Laura E. Via,P. Ling Lin,Sonja M. Ray,Jose Carrillo,Shannon Sedberry Allen,Seok Yong Eum,Kimberly L. Taylor,Edwin Klein,Ujjini H. Manjunatha,Jacqueline Gonzales,Eun Gae Lee,Seung Kyu Park,James A. Raleigh,Sang Nae Cho,David N. McMurray,JoAnne L. Flynn,Clifton E. Barry +16 more
TL;DR: Three independent lines of evidence support the hypothesis that hypoxic microenvironments are an important feature of some lesions in these animal models of tuberculosis.
Journal ArticleDOI
Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7
TL;DR: It is reported that selective exclusion of rab7, coupled with the retention of rab5 on the mycobacterial phagosome, may allow organisms from the M. tuberculosis complex to avert the usual physiological destination of phagocytosed material.
Journal ArticleDOI
Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis
Myungsun Lee,Jongmin Lee,Matthew W. Carroll,Hongjo Choi,Seonyeong Min,Taeksun Song,Laura E. Via,Lisa C. Goldfeder,Eunhwa Kang,Boyoung Jin,Hyeeun Park,Hyun-Kyung Kwak,Hyun-Chul Kim,Han Seung Jeon,Ina Jeong,Joon Sung Joh,Ray Y. Chen,Kenneth N. Olivier,Pamela A. Shaw,Dean Follmann,Sun Dae Song,Jong Koo Lee,Duk-Hyoung Lee,Cheon Tae Kim,Véronique Dartois,Seung-kyu Park,Sang Nae Cho,Clifton E. Barry +27 more
TL;DR: Linezolid is effective at achieving culture conversion among patients with treatment-refractory XDR pulmonary tuberculosis, but patients must be monitored carefully for adverse events.