M
Michael H. Cardone
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 2
Citations - 3815
Michael H. Cardone is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Apoptosis & Caspase. The author has an hindex of 2, co-authored 2 publications receiving 3772 citations.
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Journal ArticleDOI
Regulation of Cell Death Protease Caspase-9 by Phosphorylation
Michael H. Cardone,Natalie Roy,Henning R. Stennicke,Guy S. Salvesen,Thomas F. Franke,Eric J. Stanbridge,Steven M. Frisch,John C. Reed +7 more
TL;DR: In this paper, the kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro-caspase-9 (pro-Casp9) in cells.
Journal ArticleDOI
The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases
TL;DR: It is reported that a DEVD motif-specific caspase that cleaves MEKK-1 specifically is activated when cells lose matrix contact, which activates more caspases activity, comprising a positive feedback loop.