M
Michael Houghton
Researcher at University of Alberta
Publications - 249
Citations - 39279
Michael Houghton is an academic researcher from University of Alberta. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 88, co-authored 246 publications receiving 38481 citations. Previous affiliations of Michael Houghton include Chiron Corporation & Novartis.
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Journal ArticleDOI
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
TL;DR: A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis agent and screened with serum from a patient diagnosed with NANBH, showing consistent with the agent being similar to the togaviridae or flaviviridae.
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An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
George Kuo,Q L Choo,Harvey J. Alter,G.L. Gitnick,Allan G. Redeker,Robert H. Purcell,Tatsuo Miyamura,Jules L. Dienstag,M.J. Alter,Cladd E. Stevens,Gary E. Tegtmeier,Ferruccio Bonino,Massimo Colombo,W.-S. Lee,C. Kuo,K. Berger,Jeffrey R. Shuster,Lacy Rasco Overby,Daniel W. Bradley,Michael Houghton +19 more
TL;DR: Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses.
Journal ArticleDOI
Binding of Hepatitis C Virus to CD81
Piero Pileri,Yasushi Uematsu,Susanna Campagnoli,Giuliano Galli,Fabiana Falugi,Roberto Petracca,Amy J. Weiner,Michael Houghton,Domenico Rosa,Guido Grandi,Sergio Abrignani +10 more
TL;DR: Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro.
Journal ArticleDOI
Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis
Harvey J. Alter,Robert H. Purcell,James Wai-Kuo Shih,Jacqueline C. Melpolder,Michael Houghton,Qui-Lim Choo,George Kuo +6 more
TL;DR: It is concluded that hepatitis C virus is the predominant agent of transfusion-associated non-A, non-B hepatitis and that screening of donors for anti-HCV could prevent the majority of cases of the disease.