R
Robert H. Purcell
Researcher at National Institutes of Health
Publications - 666
Citations - 72118
Robert H. Purcell is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hepatitis & Virus. The author has an hindex of 139, co-authored 666 publications receiving 70366 citations. Previous affiliations of Robert H. Purcell include George Washington University & Johns Hopkins University.
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An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
George Kuo,Q L Choo,Harvey J. Alter,G.L. Gitnick,Allan G. Redeker,Robert H. Purcell,Tatsuo Miyamura,Jules L. Dienstag,M.J. Alter,Cladd E. Stevens,Gary E. Tegtmeier,Ferruccio Bonino,Massimo Colombo,W.-S. Lee,C. Kuo,K. Berger,Jeffrey R. Shuster,Lacy Rasco Overby,Daniel W. Bradley,Michael Houghton +19 more
TL;DR: Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses.
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Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis
Harvey J. Alter,Robert H. Purcell,James Wai-Kuo Shih,Jacqueline C. Melpolder,Michael Houghton,Qui-Lim Choo,George Kuo +6 more
TL;DR: It is concluded that hepatitis C virus is the predominant agent of transfusion-associated non-A, non-B hepatitis and that screening of donors for anti-HCV could prevent the majority of cases of the disease.
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Interrelationship of blood transfusion, non‐A, non‐B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus
Kendo Kiyosawa,Takeshi Sodeyama,Eiji Tanaka,Yukio Gibo,Kaname Yoshizawa,Yoshiyuki Nakano,Seiichi Furuta,Yoshihiro Akahane,Kusuya Nishioka,Robert H. Purcell,Harvey J. Alter +10 more
TL;DR: The slow, sequential progression from acute hepatitis C virus—related non‐A, non‐B hepatitis through chronic hepatitis and cirrhosis to hepatocellular carcinoma is suggested to support a causal association between hepatitis Cirus and hepato Cell carcinoma.
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Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection
Luca G. Guidotti,Rosemary Rochford,Josan Chung,Max Shapiro,Robert H. Purcell,Francis V. Chisari +5 more
TL;DR: Results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.
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Genomic analysis of the host response to hepatitis C virus infection.
Andrew I. Su,John Paul Pezacki,Lisa Wodicka,Amy D. Brideau,Lubica Supekova,Robert Thimme,Stefan Wieland,Jens Bukh,Robert H. Purcell,Peter G. Schultz,Francis V. Chisari +10 more
TL;DR: Gene expression analysis of liver biopsies in acutely infected chimpanzees reveals genome-wide transcriptional changes that reflect the establishment, spread, and control of infection, and they reveal potentially unique antiviral programs associated with clearance of HCV infection.