Michael J. Baum

TL;DR: This study confirmed the performance of RS in postmenopausal HR+ patients treated with tamoxifen in a large contemporary population and demonstrated that RS is an independent predictor of DR in N0 and N+ hormone receptor-positive patientstreated with anastrozole, adding value to estimates with standard clinicopathologic features.

TL;DR: In vivo evidence is found that 3 months of tamoxifen treatment causes a consistent induction of extracellular TGF-beta 1 in breast cancer biopsies, compared with matched pretreatment samples from the same patient.

TL;DR: The results suggest that olfactory inputs, possibly of vomeronasal origin, contribute to the activation of c-fos in the medial amygdala, and that afferent inputs from the central tegmental field and from the medial amy interact to promote cellular activity, and the resultant induction of c.fos, in the ipsilateral bed nucleus of the stria terminalis and medial preoptic area.

TL;DR: Testicular androgen may cause behavioral defeminization only in those species in which expression of feminine sexual behavior normally depends on the neural action of progesterone, acting synergistically with estradiol; new data support this claim in the ferret.

TL;DR: One of the first major randomized trials in cancer therapy was concerned with the value of postoperative adjuvant radiotherapy for breast cancer, but the impact of this treatment on long-term survival still remains clouded.