M
Michael J. Cook
Researcher at University of East Anglia
Publications - 278
Citations - 7503
Michael J. Cook is an academic researcher from University of East Anglia. The author has contributed to research in topics: Phthalocyanine & Langmuir–Blodgett film. The author has an hindex of 43, co-authored 270 publications receiving 7149 citations.
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Journal ArticleDOI
Intracellular photodynamic therapy with photosensitizer-nanoparticle conjugates: cancer therapy using a ‘Trojan horse’
Martina E. Wieder,Duncan C. Hone,Michael J. Cook,Madeleine M. Handsley,Jelena Gavrilovic,David A. Russell +5 more
TL;DR: The results suggest that gold nanoparticle conjugates are an excellent vehicle for the delivery of surface bound hydrophobic photosensitizers for efficacious photodynamic therapy of cultured tumour cells.
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Molecular Engineering of Peripherally And Axially Modified Phthalocyanines for Optical Limiting and Nonlinear Optics
Sean M. O'Flaherty,Stephanie V. Hold,Michael J. Cook,Tomás Torres,Yu Chen,Michael Hanack,Werner J. Blau +6 more
TL;DR: In this article, the authors summarize experimental measurements of nonlinear optical adsorption in a comprehensive representative series of modified phthalocyanines substituted with various central metals and peripheral functional groups.
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Generation of Cytotoxic Singlet Oxygen via Phthalocyanine-Stabilized Gold Nanoparticles: A Potential Delivery Vehicle for Photodynamic Therapy
Duncan C. Hone,Peter I. Walker,Richard Evans-Gowing,Simon FitzGerald,Andrew Beeby,Isabelle Chambrier,Michael J. Cook,David A. Russell +7 more
TL;DR: In this article, three-component (photosensitizer/gold/phase transfer reagent) nanoparticles were shown to generate singlet oxygen with enhanced quantum yields as compared to the free Pc.
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Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates
TL;DR: Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents.
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Octa-alkoxy phthalocyanine and naphthalocyanine derivatives: dyes with Q-band absorption in the far red or near infrared
TL;DR: The lithium-alkoxide-catalysed cyclic tetramerisation of various 3,6-dialkoxy-4,5-dichlorophthalonitriles, 1,4-dialkloxynaphthalene-2, 3,dicarbonitrile and 3, 6-dialknoxy-3,6 -dialkoxyctachlorophthynophthalocyanine is described in this article.