https://www.pure.ed.ac.uk/ws/files/8378925/The_benefits_and_harms_of_breast_cancer_screening.pdf

The benefits and harms of breast cancer screening: an independent review

The fourth edition of the European guidelines for quality assurance in breast cancer screening and diagnosis was published by the European Commission in 2006. The present supplements to the fourth edition have been produced by the same groups of experts originally established under the Europe Against Cancer programme that have developed and updated the guidelines since the early 1990s. Over the years, the scope and the depth of the multidisciplinary guidelines have expanded, and recommendations and protocols have been updated to keep pace with developments in the field. The present supplements lay a cornerstone for a new, completely revised fifth edition of the guidelines

/pdf/european-guidelines-for-quality-assurance-in-breast-cancer-34igkumbby.pdf

European guidelines for quality assurance in breast cancer screening and diagnosis

The connection between breast cancer and estrogen has been recognized for more than 100 years, since George Beatson demonstrated that bilateral oophorectomy resulted in the remission of breast cancer in premenopausal women.1 Subsequent evidence has implicated both endogenous and exogenous estrogen in the pathogenesis of breast cancer. In this article, we review the relation between estrogen and the risk of breast cancer. Estrogen and Breast Carcinogenesis Experimental data strongly suggest that estrogens have a role in the development and growth of breast cancer.2 Although the exact mechanisms remain to be fully elucidated, the alkylation of cellular molecules and the generation . . .

Estrogen and the Risk of Breast Cancer

The radiological appearance of the female breast varies among individuals because of differences in the relative amounts and X-ray attenuation characteristics of fat and epithelial and stromal tissues Fat is radiolucent and appears dark on a mammogram, and epithelium and stroma are radiodense and appear light We review here the evidence that these variations, known as mammographic parenchymal patterns, are related to risk of breast cancer Studies that used quantitative measurement to classify mammographic patterns have consistently found that women with dense tissue in more than 60-75% of the breast are at four to six times greater risk of breast cancer than those with no densities These risk estimates are independent of the effects of other risk factors and have been shown to persist over at least 10 years of follow up Estimates of attributable risk suggest that this risk factor may account for as many as 30% of breast cancer cases Mammographically dense breast tissue is associated both with epithelial proliferation and with stromal fibrosis The relationship between these histological features and risk of breast cancer may by explained by the known actions of growth factors that are thought to play important roles in breast development and carcinogenesis Mammographically dense tissue differs from most other breast cancer risk factors in the strength of the associated relative and attributable risks for breast cancer, and because it can be changed by hormonal and dietary interventions This risk factor may be most useful as a means of investigating the etiology of breast cancer and of testing hypotheses about potential preventive strategies

/pdf/mammographic-densities-and-breast-cancer-risk-7nnhghbyey.pdf

Mammographic densities and breast cancer risk.

https://www.pcih.fr/alip/media/consensus_prostate_2011.pdf

Magnetic Resonance Imaging for the Detection, Localisation, and Characterisation of Prostate Cancer: Recommendations from a European Consensus Meeting

Role of tomosynthesis in breast imaging going forward

Adoptive immunotherapy administered via the hepatic artery and intralesional interleukin-2 in hepatocellular carcinoma.

Image-guided breast biopsy: analysis of pain and discomfort related to technique

Case report: Mammographic and ultrasound appearances of Kaposi's sarcoma of the breast

In routine breast screening using 2D digital mammography (2DM), mediolateral-oblique (MLO) and craniocaudal (CC) views are performed to maximise cancer detection. Digital breast tomosynthesis (DBT) improves the visibility of lesions by eliminating the problem of superimposition of normal structures, and there is uncertainty regarding the need for two views. The purpose of this study is to compare the accuracy of two-view 2DM with one-view DBT.

/pdf/two-view-2d-digital-mammography-versus-one-view-digital-2jabo92m1d.pdf

Michael J Michell

Papers

Role of tomosynthesis in breast imaging going forward

Adoptive immunotherapy administered via the hepatic artery and intralesional interleukin-2 in hepatocellular carcinoma.

Image-guided breast biopsy: analysis of pain and discomfort related to technique

Case report: Mammographic and ultrasound appearances of Kaposi's sarcoma of the breast

Two-view 2D digital mammography versus one-view digital breast tomosynthesis