M
Michael J. Munson
Researcher at University of Oslo
Publications - 24
Citations - 1193
Michael J. Munson is an academic researcher from University of Oslo. The author has contributed to research in topics: Autophagy & Mitophagy. The author has an hindex of 9, co-authored 19 publications receiving 819 citations. Previous affiliations of Michael J. Munson include AstraZeneca & University of Dundee.
Papers
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Journal ArticleDOI
mito-QC illuminates mitophagy and mitochondrial architecture in vivo
Thomas G. McWilliams,Alan R. Prescott,George F. G. Allen,Jevgenia Tamjar,Michael J. Munson,Calum Thomson,Miratul M. K. Muqit,Ian G. Ganley +7 more
TL;DR: “mito-QC,” a transgenic mouse containing a pH-sensitive fluorescent mitochondrial signal, allowing in vivo detection of mitophagy and mitochondrial morphology at single-cell resolution, is presented.
Journal ArticleDOI
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.
Ruzica Bago,Nazma Malik,Michael J. Munson,Alan R. Prescott,Paul Davies,Eeva Sommer,Natalia Shpiro,Richard J. Ward,Darren Cross,Ian G. Ganley,Dario R. Alessi +10 more
TL;DR: A highly selective and potent inhibitor of Vps34, termed VPS34-IN1, is described that inhibits Vps 34 with 25 nM IC50 in vitro, but does not significantly inhibit the activity of 340 protein kinases or 25 lipid kinases tested that include all isoforms of class I as well as class II PI3Ks.
Journal ArticleDOI
mTOR activates the VPS34–UVRAG complex to regulate autolysosomal tubulation and cell survival
Michael J. Munson,George F. G. Allen,Rachel Toth,David G. Campbell,John M. Lucocq,Ian G. Ganley +5 more
TL;DR: The data imply that ALR is critical for cell survival under nutrient stress and that VPS34 is an essential regulatory element in this process.
Journal ArticleDOI
ESCRT-mediated phagophore sealing during mitophagy.
Yan Zhen,Yan Zhen,Helene Spangenberg,Helene Spangenberg,Michael J. Munson,Andreas Brech,Andreas Brech,Kay Oliver Schink,Kay Oliver Schink,Kia Wee Tan,Kia Wee Tan,Vigdis Sørensen,Vigdis Sørensen,Eva Maria Wenzel,Eva Maria Wenzel,Maja Radulovic,Maja Radulovic,Nikolai Engedal,Anne Simonsen,Camilla Raiborg,Camilla Raiborg,Harald Stenmark,Harald Stenmark +22 more
TL;DR: It is concluded that the ESCRT machinery mediates phagophore closure, and that this is essential for mitophagic flux.
Journal ArticleDOI
MTOR, PIK3C3, and autophagy: Signaling the beginning from the end.
Michael J. Munson,Ian G. Ganley +1 more
TL;DR: It is found that MTOR regulates multiple steps of ALR including direct activation of the PIK3C3-UVRAG lipid kinase complex to enable autolysosomal tubules to break away and regenerate lysosomes.