Jevgenia Tamjar

TL;DR: “mito-QC,” a transgenic mouse containing a pH-sensitive fluorescent mitochondrial signal, allowing in vivo detection of mitophagy and mitochondrial morphology at single-cell resolution, is presented.

TL;DR: The clinical relevance of the findings is substantiated by the discovery of homozygous PARKIN (PARK2) p.S65N mutations in two unrelated patients with PD and biochemical and structural analysis demonstrates that the ParkinS 65N/S65n mutant is pathogenic and cannot be activated by PINK1.

TL;DR: The structure of Tribolium castaneum PINK1 explains how PD-linked mutations that lie within the kinase domain result in hPINK1 loss-of-function and provides a platform for the exploration of small molecule modulators of hPink1.

TL;DR: This work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis and identifies an opportunity for pathogen hopping based on the structural homology between PfKRS1 and CpKRS.

TL;DR: In this paper , a drug-like series based on a fused dihydropyrrolidino-pyrimidine scaffold was developed against M tuberculosis lysyl-tRNA synthetase (LysRS) and cellular studies support this mechanism of action.