Michael Jarman

TL;DR: Repeated treatment of men with intact gonadal function with abiraterone acetate at a dose of 800 mg can successfully suppress testosterone levels to the castrate range, however, this level of suppression may not be sustained in all patients due to compensatory hypersecretion of LH.

TL;DR: Compounds having a 17-(3-pyridyl) substituent together with a 16,17-double bond have been synthesized, using a palladium-catalyzed cross-coupling reaction of a 17-enol triflate with diethyl(3- pyridol)borane, which are potent inhibitors of human testicular 17 alpha-hydroxylase-C17,20-lyase.

TL;DR: It appeared that, of the known metabolites of cyclophosphamide, only phosphoramide mustard possesses the cytoxicity and biological half-life appropriate to the active antitumour metabolite, and four other metabolites of low cytotoxicity were isolated and identified.

TL;DR: A series of isothiazolone-based HAT inhibitors were identified and chemical reactivity of these compounds, as measured by covalent protein binding and loss of HAT inhibition in the presence of DTT, indicated that reaction with thiol groups might be important in their mechanism of action.

TL;DR: A new compound can form interstrand crosslinks in the DNA of Chinese hamster V79 cells to which it is also highly toxic, findings indicative of the formation by Walker cells of a diffusible toxic metabolite of CB 1954.