M
Michael L. LaCroix-Fralish
Researcher at Dartmouth College
Publications - 25
Citations - 3204
Michael L. LaCroix-Fralish is an academic researcher from Dartmouth College. The author has contributed to research in topics: Allodynia & Nociception. The author has an hindex of 18, co-authored 22 publications receiving 2848 citations. Previous affiliations of Michael L. LaCroix-Fralish include Dartmouth–Hitchcock Medical Center & McGill University.
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Journal ArticleDOI
Coding of facial expressions of pain in the laboratory mouse
Dale J. Langford,Andrea L Bailey,Mona Lisa Chanda,Sarah E Clarke,Tanya E Drummond,Stephanie Echols,Sarah Glick,Joelle Ingrao,Tammy Klassen-Ross,Michael L. LaCroix-Fralish,Lynn C Matsumiya,Robert E. Sorge,Susana G. Sotocinal,John Tabaka,David H. W. Wong,Arn M. J. M. van den Maagdenberg,Michel D. Ferrari,Kenneth D. Craig,Jeffrey S. Mogil +18 more
TL;DR: The mouse grimace scale (MGS) is developed, a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain.
Journal ArticleDOI
Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice
Robert E. Sorge,Michael L. LaCroix-Fralish,Alexander H. Tuttle,Susana G. Sotocinal,Jean-Sebastien Austin,Jennifer Ritchie,Mona Lisa Chanda,Allyson C. Graham,Lucas Topham,Simon Beggs,Michael W. Salter,Jeffrey S. Mogil +11 more
TL;DR: It is found that activating TLR4 in the spinal cord, with the agonist lipopolysaccharide (LPS), causes robust mechanical allodynia but only in male mice, and no sex differences in spinal Tlr4 gene expression at baseline or after LPS is found, suggesting the existence of parallel spinal pain-processing circuitry in female mice not involvingTLR4.
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Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.
Andrew S.C. Rice,Dorothy Cimino-Brown,James C. Eisenach,Vesa K. Kontinen,Michael L. LaCroix-Fralish,Ian Machin,Jeffrey S. Mogil,Thomas Stöhr +7 more
TL;DR: This poster presents a poster presented at the 2016 U.S. Conference on Veterinary Medicine and Anaesthetics, entitled “Oncology and Anaesthesiology: Foundations of Comparative Oncology Research, 2nd Ed.” (June 2016).
Journal ArticleDOI
The Pain Genes Database: An interactive web browser of pain-related transgenic knockout studies.
TL;DR: The Pain Genes Database is an interactive, web‐based data browser designed to allow easy access to and analysis of the published pain‐related phenotypes of mutant mice (over 200 different mutants at the date of submission), and it is intention to update the database continually based on weekly Medline searches.
Journal ArticleDOI
Patterns of pain: Meta-analysis of microarray studies of pain
Michael L. LaCroix-Fralish,Jean-Sebastien Austin,Felix Y. Zheng,Daniel J. Levitin,Jeffrey S. Mogil +4 more
TL;DR: Two genes were identified that are consistently upregulated in chronic pain states, Reg3b (regenerating islet‐derived 3 beta; pancreatitis‐associated protein) and Ccl2 (chemokine [C–C motif] ligand 2), which were significantly upregulation in every condition in the rat.