S
Sarah E Clarke
Researcher at McGill University
Publications - 2
Citations - 1137
Sarah E Clarke is an academic researcher from McGill University. The author has contributed to research in topics: Noxious stimulus & Nociceptor. The author has an hindex of 2, co-authored 2 publications receiving 931 citations.
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Journal ArticleDOI
Coding of facial expressions of pain in the laboratory mouse
Dale J. Langford,Andrea L Bailey,Mona Lisa Chanda,Sarah E Clarke,Tanya E Drummond,Stephanie Echols,Sarah Glick,Joelle Ingrao,Tammy Klassen-Ross,Michael L. LaCroix-Fralish,Lynn C Matsumiya,Robert E. Sorge,Susana G. Sotocinal,John Tabaka,David H. W. Wong,Arn M. J. M. van den Maagdenberg,Michel D. Ferrari,Kenneth D. Craig,Jeffrey S. Mogil +18 more
TL;DR: The mouse grimace scale (MGS) is developed, a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain.
Journal ArticleDOI
The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors
Jeffrey S. Wieskopf,Jayanti Mathur,Walrati Limapichat,Michael R. Post,Mona Alqazzaz,Robert E. Sorge,Loren J. Martin,Dmitri V. Zaykin,Shad B. Smith,Kelen Freitas,Jean-Sebastien Austin,Feng Dai,Jie Zhang,Jaclyn Marcovitz,Alexander H. Tuttle,Peter Maxwell Slepian,Sarah E Clarke,Ryan M. Drenan,Jeff Janes,Shakir Al Sharari,Samantha K. Segall,Eske Kvanner Aasvang,Weike Lai,Reinhard Bittner,Christopher I. Richards,Gary D. Slade,Henrik Kehlet,John R. Walker,Uwe Maskos,Jean-Pierre Changeux,Marshall Devor,William Maixner,Luda Diatchenko,Luda Diatchenko,Inna Belfer,Dennis A. Dougherty,Andrew I. Su,Sarah C. R. Lummis,M. Imad Damaj,Henry A. Lester,Ardem Patapoutian,Jeffrey S. Mogil +41 more
TL;DR: This work identified expression levels of Chrna6, which encodes the α6 subunit of the nicotinic acetylcholine receptor (nAChR), as highly associated with allodynia, and identified the importance of α6* (α6-containing) nAChRs by analyzing both gain- and loss-of-function mutants.