M
Michael L. Macklin
Researcher at Veterans Health Administration
Publications - 32
Citations - 8118
Michael L. Macklin is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Anxiety disorder & Anterior cingulate cortex. The author has an hindex of 32, co-authored 32 publications receiving 7762 citations. Previous affiliations of Michael L. Macklin include United States Department of Veterans Affairs & Harvard University.
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Journal ArticleDOI
Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study.
Scott L. Rauch,Paul J. Whalen,Lisa M. Shin,Lisa M. Shin,Sean C. McInerney,Michael L. Macklin,Natasha B. Lasko,Scott P. Orr,Roger K. Pitman +8 more
TL;DR: This work provides the first evidence for exaggerated amygdala responses to general negative stimuli in PTSD by using a probe that emphasizes automaticity and provides initial evidence of amygdala hyperresponsivity dissociated from the "top-down" influences of medial frontal cortex.
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A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.
Lisa M. Shin,Christopher I. Wright,Paul A. Cannistraro,Michelle M. Wedig,Katherine McMullin,Brian Martis,Michael L. Macklin,Natasha B. Lasko,Sarah R. Cavanagh,Terri S. Krangel,Scott P. Orr,Roger K. Pitman,Paul J. Whalen,Scott L. Rauch +13 more
TL;DR: These results provide evidence for exaggerated amygdala responsivity, diminished medial prefrontal cortexresponsivity, and a reciprocal relationship between these 2 regions during passive viewing of overtly presented affective stimuli unrelated to trauma in PTSD.
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Regional Cerebral Blood Flow in the Amygdala and Medial Prefrontal Cortex During Traumatic Imagery in Male and Female Vietnam Veterans With PTSD
Lisa M. Shin,Scott P. Orr,Margaret A. Carson,Scott L. Rauch,Michael L. Macklin,Natasha B. Lasko,Patricia Marzol Peters,Linda J. Metzger,Darin D. Dougherty,Paul A. Cannistraro,Nathaniel M. Alpert,Alan J. Fischman,Roger K. Pitman +12 more
TL;DR: A reciprocal relationship between medial prefrontal cortex and amygdala function in PTSD and opposing associations between activity in these regions and symptom severity consistent with current functional neuroanatomic models of this disorder are suggested.
Journal ArticleDOI
De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder
Scott P. Orr,Linda J. Metzger,Natasha B. Lasko,Michael L. Macklin,Tuvia Peri,Roger K. Pitman +5 more
TL;DR: Differential conditioning was assessed in 15 medication-free individuals meeting Diagnostic and Statistical Manual of Mental Disorders criteria for chronic posttraumatic stress disorder and 18 trauma-exposed individuals who never developed PTSD (non-PTSD).
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An fMRI study of anterior cingulate function in posttraumatic stress disorder
Lisa M. Shin,Lisa M. Shin,Paul J. Whalen,Roger K. Pitman,George Bush,Michael L. Macklin,Natasha B. Lasko,Scott P. Orr,Sean C. McInerney,Scott L. Rauch +9 more
TL;DR: Findings suggest a diminished response in rostral anterior cingulate cortex in the presence of emotionally relevant stimuli in PTSD, speculate that diminished recruitment of this region in PTSD may, in part, mediate symptoms such as distress and arousal upon exposure to reminders of trauma.