M
Michael Lynch
Researcher at Arizona State University
Publications - 457
Citations - 68107
Michael Lynch is an academic researcher from Arizona State University. The author has contributed to research in topics: Population & Mutation rate. The author has an hindex of 112, co-authored 422 publications receiving 63461 citations. Previous affiliations of Michael Lynch include University of Toronto & University of Rochester.
Papers
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Journal ArticleDOI
Evolution of protein interfaces in multimers and fibrils.
W. Jeffrey Zabel,Kyle Hagner,Benjamin J Livesey,Joseph A. Marsh,Sima Setayeshgar,Michael Lynch,Paul Higgs +6 more
TL;DR: A statistical physics model that allows aggregation of proteins as either closed dimers or open fibrils of all lengths is presented and the propensities of amino acids to occur at interfaces relative to noninteracting surfaces are measured and are strongly correlated with those that have been measured in real protein structures.
Journal ArticleDOI
Silver nanoparticles elevate mutagenesis of eukaryotic genomes
TL;DR: In this article , the mutagenic effects of metal nanoparticles on the fission yeast Schizosaccharomyces pombe ATCC-16979 were evaluated.
Posted ContentDOI
One-Step PCR Amplicon Library Construction (OSPALC, version 1)
Jiahao Ni,Jiaoyi Pan,Yaohai Wang,TianHao Chen,Xinshi Feng,Yi-Chen Li,Tongtong Lin,Michael Lynch,Hongan Long,Weiyi Li +9 more
TL;DR: One-step PCR amplicon library construction (OSPALC) as discussed by the authors is a protocol for amplicon amplification in the lab along with a QIIME2-based amplicon analysis pipeline.
Journal ArticleDOI
Measuring Oligonucleotide Hydrolysis in Cellular Lysates via Viscosity Measurements.
TL;DR: This work outlines a simple alternative method for measuring DNA/RNA hydrolysis in cellular lysates, by measuring their viscosity, which only requires common laboratory supplies and a cell phone camera.
Posted ContentDOI
Evolutionary Genomics of Sister Species Differing in Effective Population Sizes and Recombination Rates
TL;DR: In this article , the authors compared population-genomics data between D. pulex and D. pulicaria, two reproductively compatible sister species experiencing ecological speciation, the first largely confined to intermittent ponds and the second to permanent lakes in the same geographic region.