M
Michael N. Chang
Researcher at Merck & Co.
Publications - 11
Citations - 171
Michael N. Chang is an academic researcher from Merck & Co.. The author has contributed to research in topics: Nucleophilic substitution & Wittig reaction. The author has an hindex of 6, co-authored 11 publications receiving 164 citations.
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Journal ArticleDOI
Lignans with platelet activating factor antagonist activity from Magnolia biondii
TL;DR: Six active lignans were isolated from the flower buds of Magnolia biondii and all six show antagonistic activities against platelet activating factor in the PAF receptor binding assay.
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Neolignans from PIPER futokadsura
Michael N. Chang,Gui-Qiu Han,Byron H. Arison,James P. Springer,San-bao Hwang,Tsung Ying Shen +5 more
TL;DR: In this article, the structures of three new neolignans, kadurenone, kadsurin A and kadurin B, isolated from Piper futokadsura were determined by chemical and spectral analysis and X-ray diffraction study.
Journal ArticleDOI
Total synthesis of kadsurenone and its analogs
Mitree M. Ponpipom,B.-Z. Yue,Robert L. Bugianesi,David R. Brooker,Michael N. Chang,T. Y. Shen +5 more
TL;DR: Kadsurenone, a specific receptor antagonist of platelet-activating factor and a natural product isolated from Piper futokadsura, was prepared in three steps from 3,4-dimethoxycinnamyl alcohol and allyloxyphenol via rac -(2S,3S)-5-allyl-6-hydroxy-2-(3, 4-dimethyl-henyl)-3-methyl-2,3-dihydrobenzofuran as discussed by the authors.
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Synthesis of δ-lactone, oxetane and azetidinone analogs from the naturally occurring β-lactone L-659,699. The preparation of a novel HMG CoA synthase inhibitor.
Kathryn L. Thompson,Michael N. Chang,Yuan-Ching P. Chiang,Shu S. Yang,John C. Chabala,Byron H. Arison,Michael D. Greenspan,D P Hanf,Joel B. Yudkovitz +8 more
TL;DR: In this article, a series of non β-lactone HMG CoA synthase inhibitors were reported, including N-tosyl azetidinone and oxetane.
Journal ArticleDOI
Quinones from Ardisia cornudentata
Z. Tian,Michael N. Chang,M. Sandrino,Leeyuan Huang,J.X. Pan,Byron H. Arison,J. Smith,Y.K.T. Lam +7 more
TL;DR: In this article, the structure of a new benzoquinone, cornudentanone, isolated from Ardisia cornudentinata M was determined, which was then used to construct a new class of benzosquinone.