Mitree M. Ponpipom

TL;DR: Results show that incorporation of synthetic glycolipids can substantially alter the in vivo lifetime and distribution of liposomes outside the bloodstream and may be useful for sustained release or selective delivery of therapeutic or diagnostic agents.

TL;DR: Adamantyl triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and the synthesis and structure-activity relationships are presented.

TL;DR: Various numbers of D-mannose residues have been attached via spacer arms to lysine, dilysine, and oligolysine backbones and the saccharide specificity of the macrophage receptor was demonstrated by the inactivity of the corresponding D-galactosyl peptide analogues.

TL;DR: Inhibitors that contained halogenated biphenylylethyl residues at P1' proved to be superior in terms of enzyme potency and oral activity with 2(R)-[2-(4'-fluoro-4-biphenylyl)ethyl]-4(S)-n- butyl-1,5-pentane dioic acid 1-(alpha(S-tert-butylglycine methylamide) amide.

TL;DR: The title compound, L-659,989, is a highly potent, competitive, and selective antagonist of the binding of [3H]PAF to its receptors in platelet membranes from rabbits and humans that exhibits equilibrium inhibition constants that are at least 1-2 orders of magnitude lower than those of other PAF antagonists tested.