M
Michael T. Lin
Researcher at Cornell University
Publications - 59
Citations - 11332
Michael T. Lin is an academic researcher from Cornell University. The author has contributed to research in topics: Mitochondrial DNA & Long-term potentiation. The author has an hindex of 36, co-authored 59 publications receiving 10271 citations. Previous affiliations of Michael T. Lin include Memorial Sloan Kettering Cancer Center & Nova Southeastern University.
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Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin,M. Flint Beal +1 more
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
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Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain
Reisuke H. Takahashi,Claudia G. Almeida,Patrick F. Kearney,Fangmin Yu,Michael T. Lin,Teresa A. Milner,Gunnar K. Gouras +6 more
TL;DR: It is demonstrated that primary neurons from Tg2576 mice recapitulate the in vivo localization and accumulation of Aβ42 with time in culture, and that A β42 aggregates into oligomers within endosomal vesicles and along microtubules of neuronal processes, which are associated with pathological alterations within processes and synaptic compartments in Tg 2576 mouse and human AD brains.
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SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines.
Thu Jennifer Ngo-Anh,Brenda L. Bloodgood,Michael T. Lin,Bernardo L. Sabatini,James Maylie,John P. Adelman +5 more
TL;DR: Blocking SK channels facilitates the induction of long-term potentiation by enhancing NMDAR-dependent Ca2+ signals within dendritic spines, mediated by a feedback loop within the spine head.
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Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.
Claudia G. Almeida,Davide Tampellini,Reisuke H. Takahashi,Paul Greengard,Michael T. Lin,Eric M. Snyder,Gunnar K. Gouras +6 more
TL;DR: It is reported that cultured Tg2576 APP mutant neurons have selective alterations in pre- and post-synaptic compartments compared to wild-type neurons, and evidence is provided that Abeta is specifically involved in these alterations in synaptic biology.
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High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer’s disease brain
TL;DR: It is found that brain mtDNA from elderly subjects had a higher aggregate burden of mutations than brain mt DNA from younger subjects, and Cytochrome oxidase activity correlated negatively with increasing mutational burden.