M
Michael T. Lin
Researcher at Cornell University
Publications - 59
Citations - 11332
Michael T. Lin is an academic researcher from Cornell University. The author has contributed to research in topics: Mitochondrial DNA & Long-term potentiation. The author has an hindex of 36, co-authored 59 publications receiving 10271 citations. Previous affiliations of Michael T. Lin include Memorial Sloan Kettering Cancer Center & Nova Southeastern University.
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Journal ArticleDOI
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.
David Simon,Michael T. Lin,Leiya Zheng,Guang-Jun Liu,Colette H. Ahn,Lauren M. Kim,William M. Mauck,Florence Twu,M. Flint Beal,Donald R. Johns +9 more
TL;DR: The results indicate that individually rare mtDNA point mutations reach a high aggregate burden in FCtx and SN of elderly subjects and there were no significant differences between Parkinson's disease patients and age-matched controls in somatic mutation levels.
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Heterologous mitochondrial DNA recombination in human cells
Marilena D'Aurelio,Carl D. Gajewski,Michael T. Lin,William M. Mauck,Leon Z. Shao,Giorgio Lenaz,Carlos T. Moraes,Giovanni Manfredi +7 more
TL;DR: Two human cytoplasmic hybrid cell lines are fused, each containing a distinct pathogenic mtDNA mutation and specific sets of genetic markers, and direct evidence of recombination between these two mtDNA haplotypes is found.
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Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease.
Michael T. Lin,Ippolita Cantuti-Castelvetri,Kangni Zheng,Katie E. Jackson,Yong B. Tan,Thomas Arzberger,Andrew J. Lees,Rebecca A. Betensky,M. Flint Beal,David Simon +9 more
TL;DR: It is shown for the first time that mtDNA mutation levels in substantia nigra neurons are significantly elevated in this group of early PD and ILBD cases.
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Triterpenoid CDDO–methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease
Magali Dumont,Elizabeth Wille,Noel Y. Calingasan,Davide Tampellini,Charlotte R. Williams,Gunnar K. Gouras,Karen T. Liby,Michael B. Sporn,M. Flint Beal,Michael T. Lin +9 more
TL;DR: The effect of the triterpenoid, CDDO‐MA, significantly improved spatial memory retention and reduced plaque burden, Aβ42 levels, microgliosis, and oxidative stress in Tg19959 mice.
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MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease
TL;DR: It is found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR -107 are associated with elevated coFilin protein levels and formation of rod-like structures in a transgenic mouse model of AD, suggesting that micro RNAs may play an important role in cytoskeletal pathology in AD.